AI Article Synopsis
- The study evaluates the effectiveness of short-term alprostadil therapy for patients with critical lower limb ischemia who can't undergo surgery, comparing it to traditional long-term treatment.
- The findings showed no significant difference in pain relief and treatment discontinuation due to side effects, with subjective pain decreasing in 83.83% of cases.
- Both treatment groups had similar results in improving trophic lesions and ankle/arm pressure, but the short-term schedule was noted for its better tolerability and efficiency, leading to easier patient management.
Article Abstract
Aim: Our study aims to evaluate the efficiency of short-term therapy with alprostadil (a PGE molecular derivative) on patients affected by critical ischemia of the lower limbs and unsuitable for surgical revascularization. The study was carried out on two groups of patients treated with the traditional long-term or a short-term protocol respectively.
Methods: The parameters evaluated and statistically compared to existing studies were, the side effects, subjective pain measured on an analogic scale, objective pain calculated according to analgesic intake, and change in trophic lesions.
Results: Our results revealed some differences between the two groups. The manifestation of side effects led to treatment suspension in 8% of long-term therapy cases only. Subjective pain was reduced or disappeared in 83.83% of cases (p<0.001) and there was no statistically significant difference between the two groups. The course of analgesic intake was again similar in both groups. Trophic lesions improved or completely healed in 64.7% (p<0.005) and although a greater tendency towards complete healing was evident in the short-term patients, it was not statistically significant. There was no significant difference between the two groups in the ankle/arm pressure index, but a significant improvement has been observed in 30.88% of cases. The results we obtained from both groups are similar and confirm the valid therapeutic use of alprostadil in patients with peripheral arterial occlusive disease (PAOD).
Conclusion: Our study reveals the presence of intrinsic advantages to the physician with the short-term schedule, through its higher tolerability, improved and more frequent patient and therapy controls and shorter hospitalization.
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