To assess the role of interleukin-6 (IL-6) in migraine, we analyzed the -174 G/C IL-6 gene polymorphism in 268 patients with migraine and 305 controls. No significant difference in the distribution of IL-6 genotypes (chi(2)=0.601, P=0.74) and allelic frequencies (chi(2)=0.024, P=0.876) was found. When patients were subdivided into subgroups (migraine with aura, migraine without aura and mixed headaches), IL-6 alleles were similarly distributed. Comparison of the clinical features of the disease with the -174 G/C IL-6 genotypes showed no significant difference. In conclusion, we found no significant association between the -174 G/C IL-6 polymorphism and the occurrence or the clinical features of migraine.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s0304-3940(03)00304-5 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
2D Flower-like CdS@Co/Mo-MOF as Co-Reaction Accelerator of g-CN-Based Electrochemiluminescence Sensor for Chlorpromazine Hydrochloride.
Biosensors (Basel)
December 2024
Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, No. 174, Shapingba Main Street, Chongqing 400030, China.
In this study, we have proposed an electrochemiluminescence (ECL) signal amplification system which is based on two-dimensional (2D) flower-like CdS@Co/Mo-MOF composites as a co-reaction accelerator of the g-CN/SO system for ultrasensitive detection of chlorpromazine hydrochloride (CPH). Specifically, the 2D flower-like Co/Mo-MOF with mesoporous alleviated the aggregation of CdS NPs while simultaneously fostering reactant-active site contact and improving the reactant-product transport rate. This allowed the material to act as a novel co-reaction accelerator, speeding up the transformation of the SO into SO and enhancing the cathodic ECL emission of g-CN.
View Article and Find Full Text PDFAn IL-6 promoter variant (-174 G/C) augments IL-6 production and alters skeletal muscle transcription in response to exercise in mice.
J Appl Physiol (1985)
December 2024
Department of Nutrition, University of Auckland, New Zealand.
Interleukin-6 (IL-6) is produced and secreted by skeletal muscle cells during exercise and plays an important role in mediating metabolic responses to exercise. The promoter region of the IL-6 gene contains a common genetic variant (-174 G/C, rs1800795) which may alter responses to exercise training. To isolate the impact of this gene variant on exercise-induced IL-6 expression and skeletal muscle transcription responses following exercise we generated knock-in mice with a GG or variant CC genotype for the murine homolog of rs1800795.
View Article and Find Full Text PDFElectroactive bacteria-established long-distance electron transfer to oxygen facilitates bio-transformation of dissolved organic matter for sediment remediation.
Water Res
November 2024
Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070, PR China; Guangdong Environmental Protection Key Laboratory of Microbiology and Ecological Safety Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070, PR China. Electronic address:
Electroactive bacteria (EAB) in sediment commonly establish long-distance electron transfer (LDET) to access O, facilitating the degradation of organic contaminants, which we hypothesize is mediated by the bio-transformation of dissolved organic matter (DOM). This study confirmed that EAB-established LDET to O via a microbial electrochemical snorkel raised the electric potential of sediment by increasing HCl-extracted Fe(III) and NO concentrations while reducing DOM concentrations, which further modified microbial diversity and composition, notably reduced the relative abundance of fermentative bacteria. As a result, DOM showed the highest SUVA value (3.
View Article and Find Full Text PDFInfluence of Interleukin Polymorphisms on the Risk of Recurrent Pregnancy Loss: A Systematic Review and Meta-analysis.
J Hum Reprod Sci
September 2024
Human Cytogenetics and Genomics Laboratory, Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, Tamil Nadu, India.
Article Synopsis
- - The study investigates the link between genetic variations in interleukin (IL) genes and the risk of recurrent pregnancy loss (RPL), finding significant associations with specific IL gene variants in a large meta-analysis of 58 studies involving 13,696 participants.
- - Key findings indicate that variations in IL-1β, IL-6, and IL-10 genes are associated with increased RPL risk, particularly in Asian populations.
- - Limitations include focusing on single-factor studies and not accounting for other factors like age or lifestyle, which could also influence RPL susceptibility.
Potential influence of interleukin-6 -174G/C gene polymorphism on kidney graft function and tacrolimus dose requirements: five-year follow-up.
Xenobiotica
October 2024
Clinic of Nephrology, University Clinical Center Nis, Nis, Serbia.
1. Introduction: The study aimed to investigate the influence of interleukin (IL)-6 -174 G/C gene polymorphism on graft function (defined as estimated glomerular filtration rate, eGFR), as well as on the tacrolimus (Tac) pharmacokinetics during the five years after kidney transplantation.
2.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!