The effects of sodium nitroprusside (N.P.), a pure smooth muscle inhibitor, on platelet function were studied. Platelet-rich plasmas (PRP) from normal controls and from patients receiving N.P. were studied in vitro for aggregation in response to adenosine diphosphate (ADP), epinephrine, and collagen. Platelet ADP release (release reaction) was also investigated. Normal platelets demonstrated marked inhibition of aggregation when incubated with N.P. for 3 min. Prolonging the incubation was without additional effect. ADP and ATP release from platelets in response to collagen was also inhibited. PRP from patients receiving nitroprusside at concentrations between 25 mug/min an 165 mug/min showed inhibition of aggregation when compared to findings prior to the administration of N.P. N.P. acts by inhibiting contractile proteins and thus platelet ADP release and aggregation may depend on contraction of platelet smooth muscle-like protein, thrombosthenin.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Nitric oxide as integral element in priming- induced tolerance and plant stress memory.
J Exp Bot
January 2025
Department of Plant Biology, University of Szeged, Közép fasor 52., H6726 Szeged, Hungary.
The beneficial effects of priming technology are aimed at the promotion of growth and development and stress tolerance in plants. Different seed pre-treatment and vegetative priming approaches (osmo-, chemical, physical, hormonal, redox treatments) increase the level of nitric oxide (NO) being an active contributor to growth regulation and defence responses. On the other hand, seed pre-treatment or vegetative priming mainly with the NO donor, sodium nitroprusside (SNP) helps to mitigate different abiotic stresses like salinity, cold, drought, excess metals.
View Article and Find Full Text PDFExogenous SNP Alleviates Drought Stress in Wheat During the Grain-Filling Stage by Modulating Gene Transcription.
Int J Mol Sci
January 2025
College of Life Sciences, Henan Agricultural University, Zhengzhou 450046, China.
Drought stress severely damages wheat growth and photosynthesis, and plants at the grain-filling stage are the most sensitive to drought throughout the entire period of development. Exogenous spraying of sodium nitroprusside (SNP) can alleviate the damage to wheat caused by drought stress, but the mechanism regulating the proline pathway remains unknown. Two wheat cultivars, drought-sensitive Zhoumai 18 and drought-tolerant Zhengmai 1860, were used as materials when the plants were cultivated to the grain-filling stage.
View Article and Find Full Text PDFAntiedemic Effect of the Myosin Light Chain Kinase Inhibitor PIK7 in the Rat Model of Myocardial Ischemia Reperfusion Injury.
Curr Issues Mol Biol
January 2025
Institute of Experimental Medicine, Almazov National Medical Research Centre, 15B Parkhomenko Street, 194021 Saint Petersburg, Russia.
Myocardial ischemia-reperfusion injury increases myocardial microvascular permeability, leading to enhanced microvascular filtration and interstitial fluid accumulation that is associated with greater microvascular obstruction and inadequate myocardial perfusion. A burst of reactive oxygen species and inflammatory mediators during reperfusion causes myosin light chain kinase (MLCK)-dependent endothelial hyperpermeability, which is considered a preventable cause of reperfusion injury. In the present study, a single intravenous injection of MLCK peptide inhibitor PIK7 (2.
View Article and Find Full Text PDFHydrogen-Bonding-Driven Design of Organic-Inorganic Hybrid Ferroelastics with Reversible Photoisomerization.
Inorg Chem
January 2025
Department of Chemistry & CICECO-Aveiro Institute of Materials, University of Aveiro, 3810-193 Aveiro, Portugal.
The development of photoresponsive ferroelastics, which couple light-induced macroscopic mechanical and microscopic domain properties, represents a frontier in materials science with profound implications for advanced functional applications. In this study, we report the rational design and synthesis of two new organic-inorganic hybrid ferroelastic crystals, (MA)(MeN)[Fe(CN)(NO)] (MA = methylammonium) () and (MA)(MeNOH)[Fe(CN)(NO)] (), using a dual-organic molecular design strategy that exploits hydrogen-bonding interactions for tailoring ferroelastic properties. Specifically, exhibits a two-step phase transition at 138 and 242 K, while the introduction of a hydroxyl group in stabilizes its ferroelastic phase to a significantly higher temperature, achieving a phase transition at 328 K, 86 K above that of .
View Article and Find Full Text PDFImpact of intravenous antihypertensive therapy on cerebral blood flow and neurocognition: a systematic review and meta-analysis.
Br J Anaesth
January 2025
Department of Anesthesia, Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address:
Background: Intravenous antihypertensivedrugs are commonly used in acute care settings, yet their impact on cerebral blood flow (CBF) remains uncertain.
Methods: A systematic review and meta-analysis of 50 studies evaluated the effects of commonly used i.v.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!