Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/j.1749-6632.2003.tb07194.x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
GSK3 inhibition improves skeletal muscle function and whole-body metabolism in male mouse models of Duchenne muscular dystrophy.
Nat Commun
November 2024
Department of Kinesiology, Brock University, St. Catharines, ON, Canada.
Article Synopsis
- * GSK3 inhibition alone or combined with aerobic exercise leads to improvements in muscle strength, endurance, insulin sensitivity, and overall metabolism in mdx mice.
- * This strategy also enhances bone health, suggesting that targeting GSK3 may offer a new treatment approach for DMD patients, contrasting with current glucocorticoid treatments that pose additional health risks.
Sucla2 Knock-Out in Skeletal Muscle Yields Mouse Model of Mitochondrial Myopathy With Muscle Type-Specific Phenotypes.
J Cachexia Sarcopenia Muscle
December 2024
Department of Medical & Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Background: Pathogenic variants in subunits of succinyl-CoA synthetase (SCS) are associated with mitochondrial encephalomyopathy in humans. SCS catalyses the conversion of succinyl-CoA to succinate coupled with substrate-level phosphorylation of either ADP or GDP in the TCA cycle. This report presents a muscle-specific conditional knock-out (KO) mouse model of Sucla2, the ADP-specific beta subunit of SCS, generating a novel in vivo model of mitochondrial myopathy.
View Article and Find Full Text PDFInhibition of CILP2 Improves Glucose Metabolism and Mitochondrial Dysfunction in Sarcopenia via the Wnt Signalling Pathway.
J Cachexia Sarcopenia Muscle
December 2024
Shengli Clinical Medical College, Fujian Medical University, Fuzhou, People's Republic of China.
Background: Skeletal muscle is the primary organ involved in insulin-mediated glucose metabolism. Elevated levels of CILP2 are a significant indicator of impaired glucose tolerance and are predominantly expressed in skeletal muscle. It remains unclear whether CILP2 contributes to age-related muscle atrophy through regulating the glucose homeostasis and insulin sensitivity.
View Article and Find Full Text PDFBacterioruberin extract from Haloarchaea Haloferax marinum: Component identification, antioxidant activity and anti-atrophy effect in LPS-treated C2C12 myotubes.
Microb Biotechnol
September 2024
Department of Bioengineering and Nano-Bioengineering, Incheon National University, Incheon, Republic of Korea.
Carotenoids are natural pigments utilized as colourants and antioxidants across food, pharmaceutical and cosmetic industries. They exist in carbon chain lengths of C, C, C and C, with C variants being the most common. Bacterioruberin (BR) and its derivatives are part of the less common C carotenoid group, synthesized primarily by halophilic archaea.
View Article and Find Full Text PDFDiarylpropionitrile-stimulated ERβ nuclear accumulation promotes MyoD-induced muscle regeneration in mdx mice by interacting with FOXO3A.
Pharmacol Res
October 2024
New drug screening center, Jiangsu Center for Pharmacodynamics Research and Evaluation, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China. Electronic address:
Duchenne muscular dystrophy (DMD) is an X-linked recessive progressive degenerative disease of skeletal muscle, characterized by intramuscular inflammation, muscle regeneration disorder and replacement of muscle with fibroadipose tissue. DMD is caused by the absence of normal dystrophy. Impaired self-renew ability and limited differentiation capacity of satellite cells are proved as main reasons for muscle regeneration failure.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!