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Explanatory Role of Conversion Surgery as a Mediator of the Mortality Risk Difference Between Patients With Unresectable Metastatic Colorectal Cancer Treated With First-Line Anti-EGFR Agents Versus Bevacizumab.
Clin Colorectal Cancer
December 2024
Department of Pharmacy, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan; Department of Public Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Introduction: Bevacizumab and antiepidermal growth factor receptor-blocking (anti-EGFR) agents plus chemotherapy are first-line therapies for metastatic colorectal cancer (mCRC). Conversion surgery may improve outcomes; however, the extent to which it explains the difference in mortality rates among treatments is unclear. Herein, we aimed to assess the effects of conversion surgery on survival outcomes of patients with unresectable mCRC treated with bevacizumab and anti-EGFR agents.
View Article and Find Full Text PDFCurrent advances in targeted therapy for metastatic colorectal cancer - Clinical translation and future directions.
Cancer Treat Rev
April 2024
State Key Laboratory of Translational Oncology, Sir YK Pao Centre for Cancer, Department of Clinical Oncology, Hong Kong Cancer Institute, The Chinese University of Hong Kong, Hong Kong Special Administrative Region. Electronic address:
Article Synopsis
- Major advancements in targeted therapy for metastatic colorectal cancer (mCRC) have been driven by progress in translational research, leading to more personalized treatment approaches in oncology.
- The selection of patients, particularly for treatments involving RAS and BRAF mutations, has significantly improved survival rates, especially with the use of drugs like cetuximab and novel inhibitors.
- Ongoing research explores innovative treatments, including anti-HER2 agents and immune-checkpoint inhibitors, along with non-invasive techniques for monitoring treatment resistance.
The relevance of the superior cervical ganglion for cardiac autonomic innervation in health and disease: a systematic review.
Clin Auton Res
February 2024
Department of Anatomy & Embryology, Leiden University Medical Center, Leiden, The Netherlands.
Purpose: The heart receives cervical and thoracic sympathetic contributions. Although the stellate ganglion is considered the main contributor to cardiac sympathetic innervation, the superior cervical ganglia (SCG) is used in many experimental studies. The clinical relevance of the SCG to cardiac innervation is controversial.
View Article and Find Full Text PDFSidedness in Unilateral Orofacial Clefts: A Systematic Scoping Review.
Cleft Palate Craniofac J
December 2023
Plastic and Maxillofacial Surgery, The Royal Children's Hospital, Melbourne, Australia.
Objective: An overview of the literature relating to the sidedness of unilateral cleft lip with or without cleft palate to map current knowledge on the cause and impact of directional asymmetry.
Design: Scoping review with a systematic search of Medline and Embase from inception to May 2023.
Patients, Participants: Humans born with a left or right unilateral cleft lip with or without a cleft palate.
Maintaining sidedness and fluidity in cell membrane coatings supported on nano-particulate and planar surfaces.
Bioact Mater
February 2024
University of Groningen and University Medical Center Groningen, Department of Biomedical Engineering, Antonius Deusinglaan 1, 9713 AV, Groningen, the Netherlands.
Supported cell membrane coatings meet many requirements set to bioactive nanocarriers and materials, provided sidedness and fluidity of the natural membrane are maintained upon coating. However, the properties of a support-surface responsible for maintaining correct sidedness and fluidity are unknown. Here, we briefly review the properties of natural membranes and membrane-isolation methods, with focus on the asymmetric distribution of functional groups in natural membranes (sidedness) and the ability of molecules to float across a membrane to form functional domains (fluidity).
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