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High-Resolution Isolation of Natural Products: Efficient Combination of Dryload Injection and HPLC Gradient Transfer.
Methods Mol Biol
January 2025
School of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland.
The isolation of pure compounds from complex extracts is a crucial step in natural products (NPs) research. Historically, this process has been recognized to be slow and laborious. However, significant advancements have been made in isolation methods.
View Article and Find Full Text PDFsgRNA Single-Nucleotide Resolution by Ion-Pairing Reversed-Phase Chromatography.
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January 2025
Synthetic Molecule Design and Development, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, United States.
Single-stranded guide RNAs (sgRNAs) are important therapeutic modalities that facilitate selective genome editing by the CRISPR/Cas9 system. While these therapeutic modalities are synthesized through solid phase oligonucleotide synthesis similar to small interfering RNA (siRNAs) and antisense oligonucleotide (ASOs) therapeutics, their sequence length and complex secondary and tertiary structure hinder analytical characterization. The resulting current sgRNA methodologies have limited chromatographic selectivity near the FLP and limited MS compatibility.
View Article and Find Full Text PDFIn-vivo high-resolution χ-separation at 7T.
Neuroimage
January 2025
Laboratory for Imaging Science and Technology, Department of Electrical and Computer Engineering, Seoul National University, Seoul, Republic of Korea. Electronic address:
A recently introduced quantitative susceptibility mapping (QSM) technique, χ-separation, offers the capability to separate paramagnetic (χ) and diamagnetic (χ) susceptibility distribution within the brain. In-vivo high-resolution mapping of iron and myelin distribution, estimated by χ-separation, could provide a deeper understanding of brain substructures, assisting the investigation of their functions and alterations. This can be achieved using 7T MRI, which benefits from a high signal-to-noise ratio and susceptibility effects.
View Article and Find Full Text PDFSAR remote sensing image segmentation based on feature enhancement.
Neural Netw
January 2025
School of Computer Science, Northwestern Polytechnical University, Xi'an 710129, China.
Synthetic aperture radar (SAR) images are crucial in remote sensing due to their ability to capture high-quality images regardless of environmental conditions. Though it has been studied for years, the following aspects still limit its further improvement. (1) Due to the unique imaging mechanism of SAR images, the influence of speckle noise cannot be avoided.
View Article and Find Full Text PDFThe metabolome of Sphingobium chinhatense IP26 exposed to chlorinated paraffins - Efficient data analysis with RASER.
Chemosphere
January 2025
Empa, Swiss Federal Laboratories for Materials Testing and Research, Laboratory for Advanced Analytical Technologies, Überlandstrasse 129, CH-8600, Dübendorf, Switzerland. Electronic address:
The universe of possible chloro-paraffin (CP) structures is a complex one. Even the world of short-chain CPs (SCCPs) is large, containing thousands of constitutional isomers and stereoisomers. We investigated a technical SCCP mixture (Hordalub 80, Vantage Leuna, m = 56%) and found 33 CP-homologues in this material with carbon- (n) and chlorine-numbers (n) varying from 10 to 13 and 4-12, respectively.
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