AI Article Synopsis
- The study examined how tissue transglutaminase (tTG) protein is expressed in various brain tumors and its potential link to tumor development.
- Using immunohistochemistry, tTG was detected in different types of tumors, revealing varied expression in tumor and endothelial cells, particularly in astrocytomas.
- Findings indicated that higher tTG expression correlated with more aggressive tumor grades, suggesting it plays a role in the malignant progression of brain tumors.
Article Abstract
Objective: To investigate expression of tissue transglutaminase (tTG) protein and its role in carcinogenesis of brain tumors.
Methods: tTG protein was detected by immunohistochemical method in 62 astrocytomas, 18 oligodendrogliomas, 30 benign meningiomas, 30 pituitary adenomas and 10 normal brain tissues.
Results: (1) In brain tumors, tTG protein expression was heterogeneous locating in tumor and endothelial cells. (2) Immunoreactivity of tTG protein was significantly different between different grades of astrocytomas. (3) Expression intensity of tTG protein in glioma was higher than that in benign brain tumors. (4) Strong expression of tTG protein in tumor cell was obtained around the necrosis foci and apoptotic cells in astrocytomas.
Conclusions: tTG protein expression contributed to tumor malignant progression in malignant brain tumors.
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