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Cancer-associated fibroblast-derived exosomal FAM83F regulates KIF23 expression to promote the malignant progression and reduce radiosensitivity in non-small cell lung cancer.
Cytotechnology
April 2025
Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing Cancer Institute, Chongqing Cancer Hospital, Chongqing University Cancer Hospital, Chongqing, 400030 China.
Unlabelled: Cancer-associated fibroblasts (CAFs) have been shown to play a crucial role in the progression of non-small cell lung cancer (NSCLC). Exosomes derived from CAFs have emerged as important mediators of intercellular communication in the tumor microenvironment, contributing to cancer progression. Therefore, it is essential to further investigate the mechanisms by which CAF-derived exosomes regulate NSCLC.
View Article and Find Full Text PDFAn Uncommon Fracture: A Case Report of a Scapular Fracture in a Young Patient.
Cureus
December 2024
Medical Research, Universidad Francisco Marroquín, Guatemala, GTM.
Scapular fractures are rare, typically resulting from high-energy trauma. These injuries frequently present alongside other thoracic or shoulder injuries. Patients often exhibit posterior shoulder pain, swelling, and limited range of motion, which can suggest a variety of shoulder pathologies.
View Article and Find Full Text PDFGiant thymolipoma in a 16-year-old girl with multimodal diagnostic approach and surgical management: a case report.
AME Case Rep
January 2025
Department of Clinical Medicine, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Background: Thymolipomas are rare benign mediastinal tumors primarily occurring in young adults, although they can also present in pediatric populations. These tumors are often asymptomatic, but their substantial size can create significant diagnostic and therapeutic challenges, necessitating careful evaluation and management.
Case Description: A teenage girl was diagnosed with a giant thymolipoma, which was discovered incidentally during a routine chest radiograph.
Importance of the multidisciplinary approach in the surgical treatment of giant mediastinal neoplasms: a case series.
AME Case Rep
November 2024
Thoracic Surgery Unit, Campus Bio-Medico University, Rome, Italy.
Background: Many reports described the importance of multidisciplinary meetings in providing oncologic patients with the best treatment strategies. This item improved overall survival, accuracy of staging and adherence to guidelines. For mediastinal neoplasms, collaboration between different surgical skills allows to deal with challenging/impossible surgical procedures.
View Article and Find Full Text PDFCircRNA circ_0015278 induces ferroptosis in lung adenocarcinoma through the miR-1228/P53 axis.
Oncol Res
January 2025
Department of Thoracic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China.
Background: Circular RNAs play an important role in regulating lung adenocarcinoma (LUAD). Bioinformatics analysis identified circ_0015278 as differentially expressed in LUAD. However, the biological mechanism of circ_0015278 in LUAD has not been fully clarified, especially in ferroptosis.
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