A case of precocious puberty occurring in a young girl is presented. Vaginal bleeding and secondary sexual characteristics had occurred at 7 years of age associated with an abdominal mass. These findings were due to a functional juvenile granulosa cell tumor in the right ovary. Right adenectomy was performed. Histopathology was confirmatory.
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Is there a role of cytoreductive surgery with HIPEC in recurrent ovarian granulosa cell tumors? An Indian cancer center experience with review of literature.
Indian J Cancer
January 2024
Department of Surgical Oncology, All India Institute of Medical Sciences, New Delhi, India.
Article Synopsis
- Granulosa cell tumors (GCTs) are common ovarian tumors associated with a good prognosis but a tendency for late recurrences, making treatment difficult.
- A study evaluated the effects of cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (HIPEC) on eight patients with recurrent adult GCTs, showing a median overall survival of 11.5 months post-treatment.
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Oncologic and fertility outcomes in patients with juvenile granulosa cell tumor - a retrospective single centre analysis.
Gynecol Oncol
November 2024
Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy; UO Gynecology, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy. Electronic address:
Background: Granulosa cell tumors (GCTs) are rare neoplasia that account for less than 5 % of all the ovarian tumors. Juvenile GCT histotype is generally observed in adolescent and young women, representing a very rare disease, so only a paucity of data are present in literature. The aim of this study is to analyse the oncologic and fertility outcome in our case series of juvenile GCTs.
View Article and Find Full Text PDFGranulosa cell tumor - Different faces of one neoplasm. A case series.
Int J Surg Case Rep
December 2024
District Public Hospital in Poznan, Poland. Electronic address:
Introduction: Granulosa cell tumor (GCT) accounts for 3-5 % of all ovarian malignancies, being the most common among those originating from the sex cords and ovarian stroma. GCTs can be divided into juvenile and adult types, with the latter occurring mostly in perimenopausal women. These hormonally active tumors present diverse clinical manifestations, primarily related to elevated estrogen levels.
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