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Unlabelled: Multiple cell death and inflammatory signaling pathways converge on two critical factors: receptor interacting serine/threonine kinase 1 (RIPK1) and caspase-8. Careful regulation of these molecules is critical to control apoptosis, pyroptosis and inflammation. Here we discovered a pivotal role of Raver1 as an essential regulator of pre-mRNA splicing, expression, and functionality, and the subsequent caspase-8-dependent inflammatory cell death.
View Article and Find Full Text PDFBehaviour of Listeria monocytogenes and Yersinia enterocolitica during beef dry-aging up to 60 days.
Int J Food Microbiol
November 2024
Department of Veterinary Medical Sciences, Alma Mater Studiorum, University of Bologna, Italy.
The Commission delegated Regulation (EU) 2024/1141 states that beef dry aging can be performed in a dedicated cabinet, at a surface temperature of -0.5 to 3 °C, maximum relative humidity of 85 %, air speed of 0.2-0.
View Article and Find Full Text PDFAurodox inhibits type III secretion in multiple Gram-negative pathogens.
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November 2024
School of Infection and Immunity, University of Glasgow, Glasgow G12 8TA, UK.
Gram-negative pathogens pose a significant threat due to their propensity for causing various infections, often coupled with formidable resistance to conventional antibiotic treatments. The development of antivirulence (AV) compounds emerges as a promising alternative strategy by disrupting virulence mechanisms rather than targeting bacterial viability. Aurodox has exhibited promising AV properties in previous studies by blocking the expression and function of the LEE-encoded type 3 secretion system (T3SS) in enterohaemorrhagic , an injectosome that translocates effector proteins directly into host target cells.
View Article and Find Full Text PDFCharacterization of two novel MCSFR paralogues in rainbow trout Oncorhynchus mykiss: New insights into the molecular mechanism underlying macrophage differentiation and modulation in fish.
Fish Shellfish Immunol
January 2025
Scottish Fish Immunology Research Centre, School of Biological Sciences, The University of Aberdeen, Aberdeen AB24 2TZ United Kingdom.
Article Synopsis
- The study investigates the colony-stimulating factor-1 receptor (MCSFR) in rainbow trout, identifying four gene variants, including two previously unrecognized, and explores their expression levels in various tissues.
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Cpx-signalling in modulates Lipid-A remodelling and resistance to last-resort antimicrobials.
NPJ Antimicrob Resist
November 2024
Centre for Bacterial Resistance Biology, Department of Life Sciences, Imperial College London, London, UK.
Antibiotic resistance is a global healthcare crisis. Bacteria are highly adaptable and can rapidly acquire mechanisms of resistance towards conventional antibiotics. The permeability barrier conferred by the Gram-negative bacteria cell envelope constitutes a first line of defence against the action of antibiotics.
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