Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/0-306-48416-1_17 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Exploring the impact of mitochondrial-targeting anthelmintic agents with GLUT1 inhibitor BAY-876 on breast cancer cell metabolism.
BMC Cancer
November 2024
Integrated Biosciences Graduate Program, University of Minnesota, 1035 Kirby Drive, Duluth, MN, 55812, USA.
Background: Cancer cells alter their metabolic phenotypes with nutritional change. Single agent approaches targeting mitochondrial metabolism in cancer have failed due to either dose limiting off target toxicities, or lack of significant efficacy in vivo. To mitigate these clinical challenges, we investigated the potential utility of repurposing FDA approved mitochondrial targeting anthelmintic agents, niclosamide, IMD-0354 and pyrvinium pamoate, to be combined with GLUT1 inhibitor BAY-876 to enhance the inhibitory capacity of the major metabolic phenotypes exhibited by tumors.
View Article and Find Full Text PDFInhalable chitosan-coated nano-assemblies potentiate niclosamide for targeted abrogation of non-small-cell lung cancer through dual modulation of autophagy and apoptosis.
Int J Biol Macromol
November 2024
Institute of Nano Science and Technology (INST), Knowledge City, Sector-81, SAS Nagar, Punjab 140306, India. Electronic address:
Lung carcinoma, particularly non-small-cell lung cancer (NSCLC), accounts for a significant portion of cancer-related deaths, with a fatality rate of approximately 19 %. Niclosamide (NIC), originally an anthelmintic drug, has attracted attention for its potential in disrupting cancer cells through various intracellular signaling pathways. However, its effectiveness is hampered by limited solubility, reducing its bioavailability.
View Article and Find Full Text PDFRafoxanide negatively modulates STAT3 and NF-κB activity and inflammation-associated colon tumorigenesis.
Cancer Sci
November 2024
Department of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy.
In the colorectal cancer (CRC) niche, the transcription factors signal transducer and activator of transcription 3 (STAT3) and nuclear factor-κB (NF-κB) are hyperactivated in both malignant cells and tumor-infiltrating leukocytes (TILs) and cooperate to maintain cancer cell proliferation/survival and drive protumor inflammation. Through drug repositioning studies, the anthelmintic drug rafoxanide has recently emerged as a potent and selective antitumor molecule for different types of cancer, including CRC. Here, we investigate whether rafoxanide could negatively modulate STAT3/NF-κB and inflammation-associated CRC.
View Article and Find Full Text PDFAdjuvants restore colistin sensitivity in mouse models of highly colistin-resistant isolates, limiting bacterial proliferation and dissemination.
Antimicrob Agents Chemother
October 2024
Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, USA.
Article Synopsis
- Antimicrobial resistance (AMR) is severely limiting the effectiveness of antibiotics, especially against Gram-negative bacteria, making global health increasingly at risk.
- Researchers highlight that the rising resistance to colistin, a last-line antibiotic for treating multi-drug resistant infections, is particularly concerning.
- The study presents new adjuvants, including IMD-0354 and novel benzimidazole compounds, which effectively restore colistin sensitivity in resistant bacterial infections in mouse models, showing low toxicity and promising results in reducing bacterial load.
In vitro synergistic antiviral activity of repurposed drugs against enterovirus 71.
Arch Virol
July 2024
Department of Central instrument and Research Laboratory, Virology and Immunology Laboratory, Chulabhorn Royal Academy, Bangkok, 10210, Thailand.
Enteroviruses cause viral diseases that are harmful to children. Hand, foot, and mouth disease (HFMD) with neurological complications is mainly caused by enterovirus 71 (EV71). Despite its clinical importance, there is no effective antiviral drug against EV71.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!