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Exploring the Link Between Infections and Primary Osteoarthritis: A Next-Generation Metagenomic Sequencing Approach.
Int J Mol Sci
December 2024
Department of Medical Microbiology, Medical University of Warsaw, Chalubinski 5 Str., 02-004 Warsaw, Poland.
This prospective pilot study examined the association between microorganisms and knee osteoarthritis by identifying pathogens in the synovial membrane, synovial fluid, and blood samples from two patients with primary bilateral knee osteoarthritis, using metagenomic next-generation sequencing (mNGS). Intraoperatively, during routine knee arthroplasty procedures, we collected the following 12 samples from each patient: two synovial membrane samples, two synovial fluid samples, and two venous blood samples. After DNA isolation and library construction, each sample was subjected to deep whole-genome sequencing using the DNBSEQT17 platform with the read length PE150 as the default.
View Article and Find Full Text PDFGenome Analysis of Japanese Yersinia pseudotuberculosis Strains Isolated From Kawasaki Disease Patients and Other Sources and Their Phylogenetic Positions in the Global Y. pseudotuberculosis Population.
Microbiol Immunol
January 2025
Department of Bacteriology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Yersinia pseudotuberculosis (Ypt) is a gram-negative bacterium that infects both humans and animals primarily through fecal‒oral transmission. While Ypt causes acute gastroenteritis in humans, an association with Kawasaki disease (KD), a disease that primarily affects infants and young children and causes multisystemic vasculitis, has also been suspected. Although KD represents a significant health concern worldwide, the highest annual incidence rate is reported in Japan.
View Article and Find Full Text PDFEffects of Yersinia pseudotuberculosis outer membrane vesicles on Pseudomonas aeruginosa antigens immune response.
PLoS One
December 2024
Engineering Research Center of Bioreactor and Drug Development, Ministry of Education, College of Life Sciences, Jilin Agricultural University, Changchun, China.
Outer membrane vesicles (OMVs) are immunogenic self-adjuvanting vesicles produced by Gram-negative bacteria such as Pseudomonas aeruginosa and Yersinia pseudotuberculosis. While the effects of OMVs on different antigens immune stimulation are not clear. In this study, we constructed recombinant Yersinia pseudotuberculosis ΔlpxL strain,with pBlue-PcrV and pBlue-OprF/I, and then purified ΔlpxL rOMVPcrV (rOMVyp2P)and ΔlpxL rOMVOprF/I (rOMVyp2F) and analyzed its effect on immune response and protection against Pseudomonas aeruginosa PAO1 infection.
View Article and Find Full Text PDFis the perilous pandemics that occurred in Asia and Europe. The bacterium has shown drug resistance that can cause the future pandemic and destroy the drug treatment against plague. As known, effective therapeutics such as designing potent vaccine that can aid world to protect against plague.
View Article and Find Full Text PDFNeutralizing chimeric anti-F1 monoclonal antibody against Yersinia pestis infection.
Int J Antimicrob Agents
December 2024
Academy of Military Medical Sciences, Beijing, China. Electronic address:
Article Synopsis
- - Drug-resistant Yersinia pestis presents a challenge for antibiotic treatment, prompting the exploration of alternative therapies like passive immunization with monoclonal antibodies (mAbs).
- - Researchers developed a murine single-chain fragment variable (scFv) phage antibody library targeting the F1 antigen and tested a chimeric mAb called S1.
- - Administering 400 μg of chimeric mAb S1 intravenously provided complete protection in a mouse model of pneumonic plague, effectively eliminating bacteria and reducing lung inflammation, suggesting it as a potential treatment for Y. pestis infections.
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