AI Article Synopsis
- Bullous morphea is a rare type of localized scleroderma characterized by long-lasting ulcers, with unclear causes and challenging treatment options.
- A patient with bullous morphea saw significant improvement and healing of ulcers within 4 months after receiving a single application of tissue-engineered skin, Apligraf.
- The success of Apligraf in this case suggests its potential effectiveness in treating chronic wounds with surrounding fibrosis, a condition known to complicate healing.
Article Abstract
Bullous morphea is an uncommon form of localized scleroderma. The exact pathogenesis is unknown and treatment of the accompanying ulcers is problematic. We report a patient with bullous morphea with long-standing ulcers whom we successfully treated with the tissue-engineered skin Apligraf (Organogenesis Inc., Canton, MA). The patient experienced rapid improvement in granulation tissue and the ulcers healed 4 months after a single application. The rationale for the use of Apligraf is based on experience with patients with venous ulcers who have surrounding peri-ulcer fibrosis. This condition, termed lipodermatosclerosis, has been reported as a poor prognostic factor for healing, yet many ulcers associated with lipodermatosclerosis may respond to treatment with tissue-engineered skin. Taken in concert, these results suggest a role for tissue- engineered skin in the treatment of chronic wounds with surrounding fibrosis.
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| http://dx.doi.org/10.1046/j.1365-4362.2003.01763.x | DOI Listing |
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(1) Background: Bullous morphea is an extremely rare form of localized scleroderma, a condition that is marked by the presence of sporadic and intermittent blisters on sclerodermatous skin. This condition stands out due to its rarity and the unique manifestation of blistering, which sets it apart from other forms of localized scleroderma. Due to the infrequent presentation of bullous morphea, there is a significant gap in our understanding of its pathogenesis.
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