AI Article Synopsis
- Aprepitant (Emend) is a new antiemetic drug that specifically targets NK(1) receptors associated with substance P.
- Blocking these NK(1) receptors in the brain's vomiting center helps reduce nausea and vomiting caused by chemotherapy.
- There's potential for NK(1) receptor blockade in other parts of the central nervous system to treat conditions like depression and stress-related disorders.
Article Abstract
Novel antiemetic agents such as the newly approved aprepitant (Emend) target receptors for substance P, known as neurokinin-1 (NK(1)) receptors. When NK(1) receptors are blocked in the vomiting center of the brainstem, chemotherapy-induced emesis is reduced. It is possible that blocking NK(1) receptors elsewhere in the CNS will lead to therapeutic actions in depression and other stress-related disorders.
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| http://dx.doi.org/10.4088/jcp.v64n0501 | DOI Listing |
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