AI Article Synopsis
- Vesicle exocytosis involves the interplay between synaptic vesicle proteins and plasma membrane proteins, often influenced by protein kinases.
- Exogenous activators of protein kinases can increase the likelihood of neurotransmitter release in various mammalian CNS synapses, although the specific physiological triggers for presynaptic kinase activation remain unclear.
- This study finds that protein kinase C (PKC) is activated by high-frequency stimulation and plays a role in post-tetanic potentiation (PTP) in the rat hippocampus.
Article Abstract
Vesicle exocytosis is mediated by the complex interaction between synaptic vesicle and plasma membrane proteins, many of which are substrates for protein kinases. Exogenous protein kinase activators increase release probability at several mammalian CNS synapses, but the physiological conditions under which presynaptic protein kinases become activated are not known. We report here that calcium/phospholipid-dependent protein kinase C (PKC) is activated by high-frequency stimulation and mediates post-tetanic potentiation (PTP) in the rat hippocampus.
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| http://dx.doi.org/10.1038/nn1067 | DOI Listing |
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