Introduction: Obesity can be defined as an excessive accumulation of health threatening body fat, caused by positive energetic balance. It can be classified according to body mass index as normal body mass, excessive body mass, significant obesity and extreme obesity. According to WHR (waist-hip ratio), it can be classified to android and gynoid type depending on fat tissue distribution. Android type has greater frequency of cardiovascular and metabolic complications, as is occurrence of premature atherosclerosis. As metabolic complications we consider lipid status disorders in obese workers, and these complications are related to body composition.
Material And Methods: Among 331 workers, we separated 95 persons with BMI > 30 kg/m2. This group was classified according to gender, their body composition has been measured using bioelectrical impedance method and, subsequently, cholesterol, triglycerides, HDL and LDL levels were determined, searching for relationship of body composition with lipid status fractions p < 0.05.
Results: High body fatty was found in 33.03% of male and in 37.48% of female subjects. It was found that in male subjects cholesterol levels (6.70 mml/L), triglycerides (2.56 mml/L), limit values of LDL (3.93 mml/L) and limit values of HDL (1.16 mml/L) were highly risky. Positive insignificant relationship of body fatty mass with cholesterol, triglycerides, LDL, but not with HDL was found.
Discussion: Results point to highly risky limit values of lipid parameters in male and female subjects. These values can be explained by older age of subjects, their way of life and nutrition regimen, significant comorbidity in this group, and influence on working ability.
Conclusion: It was found that obese male and female subjects have high values of body fatty mass. Male subjects have highly risky levels of lipid status fractions, while in female subjects these are limit values. Insignificant positive corelation of body fatty mass with lipid status fractions in tested population was found. The obtained results are significant regarding morbidity expectation and studies of complications of obese working population, as well as in judgment of working ability.
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Front Immunol
January 2025
National Key Laboratory of Draggability Evaluation and Systematic Translational Medicine, Tianjin's Clinical Research Center for Cancer, Department of Bone and Soft Tissue Tumors, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, China.
Background: Hepatocellular carcinoma (HCC) is one of the most prevalent causes of cancer-related morbidity and mortality worldwide. Late-stage detection and the complex molecular mechanisms driving tumor progression contribute significantly to its poor prognosis. Dysregulated R-loops, three-stranded nucleic acid structures associated with genome instability, play a key role in the malignant characteristics of various tumors.
View Article and Find Full Text PDFJ Trace Elem Med Biol
January 2025
Department of Fisheries and Aquaculture, University of Veterinary and Animal Sciences, Lahore, Pakistan. Electronic address:
Background: Arsenic emerges as most potent hazardous element ranked as number one in ATSDR (Agency for Toxic Substances and Disease Registry) list, can easily accumulate in fish, transported to humans via consumption and affect humans and aquatic organisms. Considering above, current experiment designed to evaluate cyto-genotoxicity and histological alterations induced by arsenic in Labeo rohita used as an animal model.
Methods: By applying complete randomized design sampling acclimatized individuals of Labeo rohita (10 batches of 10 each with triplicates) were exposed to nine definitive doses (12, 14, 16, 18, 20, 22, 24, 26 and 28 mgL) of arsenic in glass aquaria to determine 96-h lethal concentration (LC) of arsenic.
Curr Cardiol Rep
January 2025
John Ochsner Heart and Vascular Institute, Ochsner Clinical School University of Queensland School of Medicine, New Orleans, LA, USA.
Purpose Of Review: To provide a narrative overview of trends and disparities in the cardiometabolic profiles of U.S. adults by synthesizing findings from nationally representative studies conducted between 1999 and 2020.
View Article and Find Full Text PDFOncologist
January 2025
HonorHealth Research Institute, Scottsdale, AZ, United States.
Lessons Learned: Intravenous paricalcitol did not improve the efficacy of pembrolizumab, likely related to the short half-life.
Background: Immunotherapy has limited benefit in the treatment of advanced pancreatic cancer with the tumor microenvironment playing a key role in immune resistance. In preclinical studies, vitamin D receptor (VDR) agonists have been shown to sensitize pancreatic tumors to PD-1 blockade.
Geriatrics (Basel)
December 2024
Laboratorio de Investigación en Salud de Precisión, Departamento de Procesos Diagnósticos y Evaluación, Facultad de Ciencias de la Salud, Universidad Católica de Temuco, Temuco 4780000, Chile.
Frailty is a common condition among older individuals and is associated with increased vulnerability to adverse health outcomes. The COVID-19 pandemic further highlighted the impact of viral infections on frail populations. The present work aimed to determine frailty, functional and cognitive status, and clinical analysis of older persons in a long-term care facility in Chile, before and following the outbreak of COVID-19.
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