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| http://dx.doi.org/10.1093/genetics/164.1.1 | DOI Listing |
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Towards a Theory of Compassion Fatigue in Palliative Care and Oncology: A Systematic Scoping Review.
Am J Hosp Palliat Care
January 2025
Division of Supportive and Palliative Care, National Cancer Centre Singapore, Singapore.
Background: In their care of terminally ill patients, palliative care physicians and oncologists are increasingly predisposed to physical and emotional exhaustion, or compassion fatigue (CF). Challenges faced by physicians include complex care needs; changing practice demands, and sociocultural contextual factors. Efforts to better understand CF have, however, been limited.
View Article and Find Full Text PDFMembrane Proteins in Nanodiscs: Methods and Applications.
ChemMedChem
January 2025
Nankai University, State Key Laboratory of Elemento-Organic Chemistry and Department of Chemical Biology, College of Chemistry, 94 Weijin Road, 300071, Tianjin, CHINA.
Membrane proteins, a principal class of drug targets, play indispensable roles in various biological processes and are closely associated with essential life functions. Their study, however, is complicated by their low solubility in aqueous environments and distinctive structural characteristics, necessitating a suitable native-like environment for molecular analysis. Nanodisc technology has revolutionized this field, providing biochemists with a powerful tool to stabilize membrane proteins and significantly enhance their research possibilities.
View Article and Find Full Text PDFHuman epidermal growth factor receptor 2 (HER2, also known as ERBB2) signaling promotes cell growth and differentiation, and is overexpressed in several tumor types, including breast, gastric and colorectal cancer. HER2-targeted therapies have shown clinical activity against these tumor types, resulting in regulatory approvals. However, the efficacy of HER2 therapies in tumors with HER2 mutations has not been widely investigated.
View Article and Find Full Text PDFWorking-memory load decoding model inspired by brain cognition based on cross-frequency coupling.
Brain Res Bull
January 2025
School of Life and Health Information Science and Engineering, Chongqing University of Posts and Telecommunications, Chongqing 400065, China; College of Computer Science and Technology, Chongqing University of Posts and Telecommunications, Chongqing 400065, China; Institute for Advanced Sciences, Chongqing University of Posts and Telecommunications, Chongqing 400065, China; Guangyang Bay Laboratory, Chongqing Institute for Brain and Intelligence, Chongqing 400064, China. Electronic address:
Working memory, a fundamental cognitive function of the brain, necessitates the evaluation of cognitive load intensity due to limited cognitive resources. Optimizing cognitive load can enhance task performance efficiency by preventing resource waste and overload. Therefore, identifying working memory load is an essential area of research.
View Article and Find Full Text PDFLong somatic DNA-repeat expansion drives neurodegeneration in Huntington's disease.
Cell
January 2025
Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Program in Neuroscience, Harvard Medical School, Boston, MA 02215, USA; Howard Hughes Medical Institute, Boston, MA 02215, USA. Electronic address:
In Huntington's disease (HD), striatal projection neurons (SPNs) degenerate during midlife; the core biological question involves how the disease-causing DNA repeat (CAG) in the huntingtin (HTT) gene leads to neurodegeneration after decades of biological latency. We developed a single-cell method for measuring this repeat's length alongside genome-wide RNA expression. We found that the HTT CAG repeat expands somatically from 40-45 to 100-500+ CAGs in SPNs.
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