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The role of serine/threonine protein phosphatases in exocytosis. | LitMetric

The role of serine/threonine protein phosphatases in exocytosis.

Biochem J

School of Biomedical Sciences, Faculty of Health, University of Newcastle, and Clinical Neuroscience Program, Hunter Medical Research Institute, Callaghan, NSW 2308, Australia.

Published: August 2003

Modulation of exocytosis is integral to the regulation of cellular signalling, and a variety of disorders (such as epilepsy, hypertension, diabetes and asthma) are closely associated with pathological modulation of exocytosis. Emerging evidence points to protein phosphatases as key regulators of exocytosis in many cells and, therefore, as potential targets for the design of novel therapies to treat these diseases. Diverse yet exquisite regulatory mechanisms have evolved to direct the specificity of these enzymes in controlling particular cell processes, and functionally driven studies have demonstrated differential regulation of exocytosis by individual protein phosphatases. This Review discusses the evidence for the regulation of exocytosis by protein phosphatases in three major secretory systems, (1) mast cells, in which the regulation of exocytosis of inflammatory mediators plays a major role in the respiratory response to antigens, (2) insulin-secreting cells in which regulation of exocytosis is essential for metabolic control, and (3) neurons, in which regulation of exocytosis is perhaps the most complex and is essential for effective neurotransmission.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1223558PMC
http://dx.doi.org/10.1042/BJ20030484DOI Listing

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