In the Indian traditional system of medicine Withania somnifera Dun. is widely regarded as the Indian Ginseng. A new withanolide-free hydrosoluble fraction was isolated from the roots of Withania somnifera Dun. and was evaluated for putative antistress activity against a battery of tests to delineate the activity of this fraction. The latter fraction exhibited significant antistress activity in a dose-related manner (Singh et al., 2001) and was further studied against chemical and physical induced stress in rats and mice. The extract of Withania somnifera root (a commercial preparation available locally) was also used to compare the results. A preliminary acute toxicity study in mice showed a good margin of safety with a high therapeutic index.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/ptr.1189 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Structural and functional characterization of genes and enzymes involved in withanolide biosynthesis in Physalis alkekengi L.
Steroids
December 2024
Genome Research Laboratory, School of Biotechnology, University of Jammu, Jammu 180006, India. Electronic address:
Physalis alkekengi L. is recognized as a significant source of various secondary metabolites, particularly C steroidal lactones known as withanolides and physalins, renowned for their therapeutic properties with a rich history in traditional medicine. In this study, we characterized the sequences of key downstream genes (PaFPPS, PaSQS, PaSQE, PaCAS, PaHYD1, and PaDWF5-1) involved in the biosynthesis of withanolides, marking the first characterization of these genes in P.
View Article and Find Full Text PDFInternal transcribed spacer (ITS): The powerful DNA barcode and phylogenetic marker for successful authentication of Withania somnifera.
Mol Biol Rep
December 2024
R&D Healthcare Division, Emami Limited, 13 B.T Road, Belgharia, Kolkata, West Bengal, 700056, India.
Background: Understanding the evolutionary history of plants and accurately identifying biologically important species and their families is crucial for the herbal and Ayurvedic industries. The genetic approach by DNA barcoding plays a pivotal role in accurate species identification, authentication and quality control. Due to various therapeutic properties, Withania somnifera has been used worldwide in traditional systems of medicine for centuries including Ayurveda and Unani.
View Article and Find Full Text PDFSunlight-driven photocatalytic degradation of industrial dyes using Withania somnifera decorated MnO nanoparticles.
Discov Nano
December 2024
Department of Chemistry, School of Applied and Life Sciences, Uttaranchal University, Dehradun, Uttarakhand, 248007, India.
This study presents a unique, fast, and environmentally friendly approach for synthesizing MnO nanoparticles (MnO NPs) utilizing Withania somnifera (Ashwagandha) extract. The formation of nanoparticles was indicated by a color change from dark purple to dark brown within 10 min and validated through techniques including UV-Vis spectroscopy, Field Emission Scanning Electron Microscopy (FESEM), Fourier Transform Infrared Spectroscopy (FTIR), and Energy Dispersive X-ray (EDX). Bromocresol green and Bromothymol blue were established as standards for assessing the photocatalytic efficiency of the synthesized nanoparticles.
View Article and Find Full Text PDFImpact of a and Formulation on SH-SY5Y Human Neuroblastoma Cells Metabolism Through NMR Metabolomic.
Nutrients
November 2024
Department of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano, Italy.
: This study investigates the effectiveness of an herbal formulation, STRESSLESS (ST-65), which combines ashwagandha () and bacopa (), on SH-SY5Y human neuroblastoma cells. Given the rising interest in natural compounds for neuroprotection and stress alleviation, we aimed to explore the cellular and molecular effects of this formulation. : Utilizing a nuclear magnetic resonance (NMR) metabolomic approach and ultra-high-performance liquid chromatography-high-resolution mass spectrometry (UHPLC-HRMS), we identified key bioactive compounds in ST-65, including withanolides from ashwagandha and bacosides from bacopa.
View Article and Find Full Text PDFAshwagandha (Withania somnifera (L.) dunal) root extract containing withanolide a alleviates depression-like behavior in mice by enhancing the brain-derived neurotrophic factor pathway under unexpected chronic mild stress.
J Ethnopharmacol
December 2024
Korea Food Research Institute, Wanju-gun, Jeonbuk STATE 55365, Republic of Korea. Electronic address:
Ethnopharmacological Relevance: Ashwagandha (Withania somnifera (L.) Dunal) root or whole-plant extracts are used to treat anxiety, insomnia, and other nervous system disturbances.
Aim Of The Study: We evaluated the neuroprotective and antidepressant effects of ashwagandha root extract (ARE) on corticosterone-exposed HT-22 cells and unpredictable chronic mild stress (UCMS)-challenged mice.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!