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http://dx.doi.org/10.1002/anie.200351058 | DOI Listing |
Alzheimers Dement
December 2024
Laboratory of Clinical Investigation, National Institute on Aging, Intramural Research Program, Baltimore, MD, USA.
Background: In 2016, we introduced the Bayesian Monte Carlo analysis of multicomponent-driven equilibrium observation of T and T (BMC-mcDESPOT) MRI method for myelin water fraction (MWF) mapping, a surrogate of myelin content. While BMC-mcDESPOT has been extensively applied to study brain aging, dementias, and risk factors influencing myelination, it still requires a lengthy acquisition time (∼17 min) which hampers its integration in clinical studies and trials. In this study, we aim to accelerate the BMC-mcDESPOT method for whole brain, high-resolution, MWF mapping within clinically feasible scan time of ∼6 min.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Laboratory of Clinical Investigation, National Institute on Aging, Intramural Research Program, Baltimore, MD, USA.
Background: In 2016, we introduced the Bayesian Monte Carlo analysis of multicomponent-driven equilibrium observation of T1 and T2 (BMC-mcDESPOT) MRI method for myelin water fraction (MWF) mapping, a surrogate of myelin content. While BMC-mcDESPOT has been extensively applied to study brain aging, dementias, and risk factors influencing myelination, it still requires a lengthy acquisition time (∼17 min) which hampers its integration in clinical studies and trials. In this study, we aim to accelerate the BMC-mcDESPOT method for whole brain, high-resolution, MWF mapping within clinically feasible scan time of ∼6 min.
View Article and Find Full Text PDFTalanta
January 2025
Key Disciplines Lab of Novel Micro-Nano Devices and System Technology, Key Laboratory of Optoelectronic Technology and Systems, Ministry of Education, Chongqing University, Shapingba, Chongqing, 400044, China; School of Optoelectronic Engineering, Chongqing University, Shapingba, Chongqing, 400044, China. Electronic address:
The effective qualitative and quantitative detection of mixed components of volatile organic compounds (VOCs) with similar molecular structures has always been a challenge and hotpoint in the research. A novel quartz-crystal microbalance (QCM) nanocomposite sensor integrated with a surface-enhanced Raman scattering (SERS) detection platform for multi-component gas analysis was proposed and fabricated in this paper. MIL-100 (Fe)/PAN composite fibers were developed on QCM via electrospinning of polyacrylonitrile (PAN) and hydrothermal synthesis, addressing the integration issues of MIL-100 particles in devices while maintaining high specific surface area.
View Article and Find Full Text PDFScand J Med Sci Sports
January 2025
Department of Physical Education and Sports, Faculty of Sport Sciences, University of Granada, Melilla, Spain.
We aimed to determine the persisting effects of various exercise modalities and intensities on functional capacity after periods of training cessation in older adults. A comprehensive search was conducted across the Cochrane Library, PubMed/MEDLINE, Scopus, and Web of Science Core Collection up to March 2024 for randomized controlled trials examining residual effects of physical exercise on functional capacity in older adults ≥ 60 years. The analysis encompassed 15 studies and 21 intervention arms, involving 787 participants.
View Article and Find Full Text PDFZ Evid Fortbild Qual Gesundhwes
January 2025
Department Digital Health Sciences and Biomedicine, School of Life Sciences, University of Siegen, Siegen, Germany.
Background: Pregnant women and their families, especially those navigating chronic illness or challenging life situations, often seek information and counseling. The pregnancy period and the transition to parenthood can exacerbate these circumstances, leaving families particularly vulnerable. Addressing stressful situations becomes a hurdle in this context.
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