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Clinical and laboratory characteristics of Sjögren's syndrome-associated autoimmune liver disease: a real-world, 10-year retrospective study.
Clin Rheumatol
January 2025
Department of Rheumatology and Immunology, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.
Objectives: To investigate the clinical and laboratory features of Sjögren's syndrome-associated autoimmune liver disease (SS-ALD) patients and identify potential risk and prognostic factors.
Methods: SS patients with or without ALD, who visited Tongji Hospital between the years 2011 and 2021 and met the 2012 American College of Rheumatology (ACR) classification criteria for Sjögren's syndrome, were retrospectively enrolled. The clinical and laboratory data of the enrolled patients, including autoimmune antibodies, were collected and analyzed with principal component analysis, correlation analysis, LASSO regression, and Cox regression.
SARS-CoV-2 seropositivity amongst healthcare workers in South Africa during the Omicron wave: natural infection versus vaccination.
J Clin Pathol
January 2025
Department of Clinical Pathology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa
Aims: Concerns over population-level immunity have been heightened with each successive wave of COVID-19, prompting questions about whether it is primarily derived from vaccination efforts or from previous natural infections with the virus. We wished to determine the seroprevalence of SARS-CoV-2 antibodies among healthcare workers (HCWs) in Pretoria (Tshwane), South Africa, and to establish whether they were derived from vaccination or natural infection.
Methods: Serum samples were collected from HCWs during the fourth wave of COVID-19 between 1 December 2021 and 13 March 2022.
Immunoinformatic based designing of highly immunogenic multi-epitope subunit vaccines to stimulate an adaptive immune response against Junin virus.
Mol Divers
December 2024
Centre for Biotechnology and Microbiology, University of Swat, Swat, Pakistan.
The Junin virus causes Argentine hemorrhagic fever, leading to severe complications such as high fever, malaise, muscle pain, and bleeding disorders, including hemorrhages in the skin and mucous membranes. Neurological issues like confusion, seizures, and coma can also occur. Without prompt and effective treatment, the disease can be fatal, with mortality rates reaching up to 30%.
View Article and Find Full Text PDFAnti-Modified Peptide Antibodies (AMPAs) in Rheumatoid Arthritis: Study of the Diagnostic Value of Citrullinated, Homocitrullinated, and Acetylated Fibrin/Filaggrin Chimeric Peptides.
Diagnostics (Basel)
November 2024
Unit of Synthesis and Biomedical Applications of Peptides, IQAC-CSIC, Jordi Girona 18-26, 08034 Barcelona, Spain.
The presence of anti-citrullinated peptide/protein antibodies (ACPAs), anti-carbamylated peptide/protein antibodies (anti-CarPs), and anti-acetylated peptide/protein antibodies (AAPAs), collectively termed as anti-modified peptide/protein antibodies (AMPAs), is a hallmark of rheumatoid arthritis. These autoantibodies play a crucial role in the complex autoimmune responses observed in patients. Understanding the interplay between them is essential for early diagnosis and effective management of the disease.
View Article and Find Full Text PDFApplication of immunoinformatics to develop a novel and effective multiepitope chimeric vaccine against Variovorax durovernensis.
Comput Biol Chem
December 2024
Department of Medical Administration, Zhejiang Province People Hospital, Affiliated People Hospital, Hangzhou Medical College Hangzhou, Zhejiang, PR China. Electronic address:
Article Synopsis
- Bloodstream infections from resistant bacteria like Variovorax durovernensis are a major public health threat, highlighting the need for effective preventive measures.
- This study utilized reverse vaccinology to identify and design a multiepitope vaccine targeting an outer membrane protein (OmpA family protein) from V. durovernensis, resulting in the identification of notable immunogenic epitopes.
- The crafted vaccine was shown to effectively provoke strong immune responses, evidenced by significant antibody production, supporting its potential for broad population coverage against the bacterium.
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