The confirmatory factor structure of the Finnish version of the Dissociative Experiences Scale II (DES-II) was exactly the same in the non-clinical population (n=924) as was found in the most recent study in the USA (with the original English version) and as suggested by the authors of the original version. The Finnish version of the DES-II has a Cronbach's alpha of 0.92, and there is a clear positive correlation (from 0.31 to 0.66) between all 28 items and the total score (P<0.001 for all items), indicating good internal consistency and reliability. We also investigated dissociative experiences and psychiatric distress with the DES-II and the General Health Questionnaire (GHQ-12). The increased proportion of "pathological dissociation" (DES-T) to "non-pathological dissociation" (DES-NP) was directly linked with increased distress. This finding is meaningful for the debate on the utility of the different DES-II scoring systems.
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http://dx.doi.org/10.1080/08039480310000211 | DOI Listing |
Clin J Am Soc Nephrol
January 2025
Nephrology Department, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Key Points: We observed a comparable cumulative incidence of major adverse cardiovascular event (MACE) in in-center hemodialysis (IC-HD) and continuous ambulatory peritoneal dialysis (PD) patients, which was higher than in automated PD and home hemodialysis patients. After adjustment for confounders, there was no difference in risk of MACE between patients on home dialysis modalities and IC-HD. Compared with IC-HD, PD was associated with lower risk of MACE among female patients and higher risk among male patients.
View Article and Find Full Text PDFDiabetologia
January 2025
Department of Public Health, University of Helsinki, Helsinki, Finland.
Aims/hypothesis: Eating disorders are over-represented in type 1 diabetes and are associated with an increased risk of complications, but it is unclear whether type 1 diabetes affects the treatment of eating disorders. We assessed incidence and treatment of eating disorders in a nationwide sample of individuals with type 1 diabetes and diabetes-free control individuals.
Methods: Our study comprised 11,055 individuals aged <30 who had been diagnosed with type 1 diabetes in 1998-2010, and 11,055 diabetes-free control individuals matched for age, sex and hospital district.
Archaeol Anthropol Sci
December 2024
Department of Cultures, Archaeology, University of Helsinki, Helsinki, Finland.
J Cheminform
December 2024
Department of Computer Science, Aalto University, 02150, Espoo, Finland.
Machine learning (ML) systems have enabled the modelling of quantitative structure-property relationships (QSPR) and structure-activity relationships (QSAR) using existing experimental data to predict target properties for new molecules. These property predictors hold significant potential in accelerating drug discovery by guiding generative artificial intelligence (AI) agents to explore desired chemical spaces. However, they often struggle to generalize due to the limited scope of the training data.
View Article and Find Full Text PDFCell Mol Life Sci
December 2024
Medical Faculty, Martin Luther University Halle-Wittenberg, Magdeburger Str. 2, 06112, Halle (Saale), Germany.
Angiotensensin-converting enzyme-2 (ACE2) is a receptor for SARS-CoV-2, allowing the virus to enter cells. Although tumor patients infected by SARS-CoV-2 often have a worse outcome, the expression, function and clinical relevance of ACE2 in tumors has not yet been thoroughly analyzed. In this study, RNA sequencing (RNA-seq) data from tumors, adjacent tissues and whole blood samples of COVID-19 patients from genome databases and from tumor cell lines and endothelial cells infected with different SARS-CoV-2 variants or transfected with an ACE2 expression vector (ACE2) or mock (ACE2) were analyzed for the expression of ACE2 and immune response relevant molecules in silico or by qPCR, flow cytometry, Western blot and/or RNA-seq.
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