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Associations between circulating interleukin-18 levels and adult-onset Still's disease: a meta-analysis.
J Rheum Dis
January 2025
Division of Rheumatology, Department of Internal Medicine, Korea University Medical Center, Korea University College of Medicine, Seoul, Korea.
Objective: This study aimed to investigate the link between circulating interleukin-18 (IL-18) levels and adult-onset Still's disease (AOSD).
Methods: A thorough search was performed on MEDLINE, Embase, and Web of Science to find relevant articles. A meta-analysis was conducted to compare serum/plasma IL-18 levels in AOSD patients to those in control subjects.
Intestinal fatty acid binding protein is associated with coronary artery disease in long-term type 1 diabetes-the Dialong study.
Cardiovasc Diabetol
November 2024
Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, Oslo, Norway.
Article Synopsis
- Individuals with long-term type 1 diabetes may have an increased risk of heart issues due to inflammation caused by gut microbiota entering the bloodstream, leading to atherosclerosis.
- A study involving 102 people with type 1 diabetes and 63 controls measured several biomarkers related to gut inflammation and assessed coronary atherosclerosis using advanced imaging techniques.
- The results indicated that higher levels of intestinal fatty acid binding protein (I-FABP) were linked to significant coronary artery blockages, suggesting it could be a potential marker for heart disease in diabetes patients.
Decoy-resistant IL-18 reshapes the tumor microenvironment and enhances rejection by anti-CTLA-4 in renal cell carcinoma.
JCI Insight
November 2024
Section of Medical Oncology, Yale School of Medicine, New Haven, United States of America.
The cytokine interleukin-18 (IL-18) has immunostimulatory effects but is negatively regulated by a secreted binding protein, IL-18BP, that limits IL-18's anti-cancer efficacy. A "decoy-resistant" form of IL-18 (DR-18), that avoids sequestration by IL-18BP while maintaining its immunostimulatory potential, has recently been developed. Here, we investigated the therapeutic potential of DR-18 in renal cell carcinoma (RCC).
View Article and Find Full Text PDFIL-9 sensitizes human T2 cells to proinflammatory IL-18 signals in atopic dermatitis.
J Allergy Clin Immunol
November 2024
Department of Dermatology, Inselspital, Bern University Hospital, Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland. Electronic address:
Background: T2 cells crucially contribute to the pathogenesis of atopic dermatitis (AD) by secreting high levels of IL-13 and IL-22. Yet the upstream regulators that activate T2 cells in AD skin remain unclear. IL-18 is a putative upstream regulator of T2 cells because it is implicated in AD pathogenesis and has the capacity to activate T cells.
View Article and Find Full Text PDFElevated levels of peripheral and central nervous system immune markers reflect innate immune dysregulation in autism spectrum disorder.
Psychiatry Res
December 2024
K.G. Jebsen Center for Neurodevelopmental Disorders, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Medical Genetics, Oslo University Hospital, building 25, Kirkeveien 166, Oslo 0450, Norway; Department of Clinical Science, NORMENT, University of Bergen, Bergen, Norway. Electronic address:
Background: Evidence suggests dysregulated immune functions in the pathophysiology of Autism spectrum disorder (ASD), although specific immune mechanisms are yet to be identified.
Methods: We assessed circulating levels of 25 immune/neuroinflammatory markers in a large ASD sample (n = 151) and matched controls (n = 72) using linear models. In addition, we performed global brain transcriptomics analyses of relevant immune-related genes.
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