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111 years of allergen-immunotherapy: A long and successful history of the only available disease-modifier in allergic diseases.
Allergol Select
November 2022
Department of Dermatology and Allergology Biederstein, Technical University Munich, Munich, Germany.
Article Synopsis
- The development of allergen-specific immunotherapy (AIT) has a long and complex history, with roots tracing back to the early 1900s, notably marked by Noon and Freeman's influential work in 1911.
- Various methods were explored over the years for administering allergen extracts, including subcutaneous, oral, and other innovative routes.
- Bill Franklin played a crucial role in advancing AIT to an evidence-based practice by emphasizing the importance of controlled clinical observations and placebo comparisons in documenting its effects.
Radical Cystectomy Against Intravesical BCG for High-Risk High-Grade Nonmuscle Invasive Bladder Cancer: Results From the Randomized Controlled BRAVO-Feasibility Study.
J Clin Oncol
January 2021
Clinical Trials Research Unit, Leeds Institute for Clinical Trials Research, University of Leeds, Leeds, United Kingdom.
Purpose: High-grade nonmuscle invasive bladder cancer (HRNMIBC) is a heterogeneous disease. Treatments include intravesical maintenance (mBCG) and radical cystectomy (RC). We wanted to understand whether a randomized trial comparing these options was possible.
View Article and Find Full Text PDFThe evolution of allergy immunotherapy.
Ann Allergy Asthma Immunol
April 2021
Division of Allergy and Clinical Immunology, Department of Medicine, National Jewish Health, Denver, Colorado. Electronic address:
Objective: The objective of this review is to trace the evolution of the art and science of allergy immunotherapy (AIT).
Data Sources: Original reports relating to the evolution of the concept of respiratory allergy and its specific treatment were identified by following references in journal articles, review articles, and allergy textbooks from the mid-20th century to the present.
Study Selections: Studies highlighting substantial milestones in the evolution of the practice of allergy immunotherapy were included.
The Lived Experience and Legacy of Pragmatics for Deaf and Hard of Hearing Children.
Pediatrics
November 2020
The Global Coalition of Parents of Children Who Are Deaf and Hard of Hearing, Como, Italy; and.
In this article, we discuss deaf and hard of hearing (DHH) children's pragmatic difficulties and strengths from within the lived experiences of 5 hearing parents of DHH children and 5 DHH adults (one of whom is also a parent of a deaf child). We define lived experience as both a specific form of knowledge (first-hand stories from everyday life) and a unique way of knowing (reflecting and telling from insider perspectives). The parents and DHH adults involved coauthored the article alongside 2 experienced researcher-practitioners.
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