The morphological analysis of major processes involved in cardiac myogenesis (including cytodifferentiation, proliferation, integration and apoptosis) was carried out by studying the myocardium of 52 human embryos at weeks 4 to 8 of development. The data provided by this study, permit to draw a conclusion on the coupling of high proliferative activity of cardiomyocytes, their active divergent differentiation, formation of the integrative intercellular communications and manifestations of programmed cell death relations during this period of ontogenesis. Starting with week 6 of intrauterine life, the developing atrial and ventricular cardiac muscular tissue demonstrates the heteromorphy of constituting cardiomyocytes, which differentiate into three types: contractile, contractile-secretory and conducting ("light").
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
An autocrine synergistic desmin-SPARC network promotes cardiomyogenesis in cardiac stem cells.
Cells Dev
December 2024
Max Perutz Labs, Vienna Biocenter Campus (VBC), Vienna, Austria; Medical University of Vienna, Center for Medical Biochemistry, Department of Molecular Biology, Vienna, Austria. Electronic address:
The mammalian heart contains cardiac stem cells throughout life, but it has not been possible to harness or stimulate these cells to repair damaged myocardium in vivo. Assuming physiological relevance of these cells, which have evolved and have been maintained throughout mammalian evolution, we hypothesize that cardiac stem cells may contribute to cardiomyogenesis in an unorthodox manner. Since the intermediate filament protein desmin and the matricellular Secreted Protein Acidic and Rich in Cysteine (SPARC) promote cardiomyogenic differentiation during embryogenesis in a cell-autonomous and paracrine manner, respectively, we focus on their genes and employ mouse embryonic and cardiac stem cell lines as in vitro models to ask whether desmin and SPARC cooperatively influence cardiomyogenesis in cardiac stem and progenitor cells.
View Article and Find Full Text PDFRbm24-mediated post-transcriptional regulation of skeletal and cardiac muscle development, function and regeneration.
J Muscle Res Cell Motil
November 2024
College of Marine Life Sciences, Institute of Evolution & Marine Biodiversity, Ocean University of China, Qingdao, 266003, China.
RNA-binding proteins are critically involved in the post-transcriptional control of gene expression during embryonic development and in adult life, contributing to regulating cell differentiation and maintaining tissue homeostasis. Compared to the relatively well documented functions of transcription factors, the regulatory roles of RNA-binding proteins in muscle development and function remain largely elusive. However, deficiency of many RNA-binding proteins has been associated with muscular defects, neuromuscular disorders and heart diseases, such as myotonic dystrophy, amyotrophic lateral sclerosis, and cardiomyopathy.
View Article and Find Full Text PDFThe importance of matrix in cardiomyogenesis: Defined substrates for maturation and chamber specificity.
Matrix Biol Plus
December 2024
School of Chemistry, UNSW Sydney, Sydney, New South Wales, Australia.
Human embryonic stem cell-derived cardiomyocytes (hESC-CM) are a promising source of cardiac cells for disease modelling and regenerative medicine. However, current protocols invariably lead to mixed population of cardiac cell types and often generate cells that resemble embryonic phenotypes. Here we developed a combinatorial approach to assess the importance of extracellular matrix proteins (ECMP) in directing the differentiation of cardiomyocytes from human embryonic stem cells (hESC).
View Article and Find Full Text PDFAlternative polyadenylation and dynamic 3' UTR length is associated with polysome recruitment throughout the cardiomyogenic differentiation of hESCs.
Front Mol Biosci
February 2024
Bioinformatics Unit, Pasteur Institute of Montevideo, Montevideo, Uruguay.
Alternative polyadenylation (APA) increases transcript diversity through the generation of isoforms with varying 3' untranslated region (3' UTR) lengths. As the 3' UTR harbors regulatory element target sites, such as miRNAs or RNA-binding proteins, changes in this region can impact post-transcriptional regulation and translation. Moreover, the APA landscape can change based on the cell type, cell state, or condition.
View Article and Find Full Text PDFCell Differentiation and Aging Lead To Up-Regulation of FTO, While the ALKBH5 Protein Level Was Stable During Aging but Up-Regulated During in vitro-Induced Cardiomyogenesis.
Physiol Res
August 2023
Department of Cell Biology and Epigenetics, Institute of Biophysics, Academy of Sciences of the Czech Republic, Brno, Czech Republic.
FTO and ALKBH5 proteins are essential erasers of N6-adenosine methylation in RNA. We studied how levels of FTO and ALKBH5 proteins changed during mouse embryonic development, aging, cardiomyogenesis, and neuroectodermal differentiation. We observed that aging in male and female mice was associated with FTO up-regulation in mouse hearts, brains, lungs, and kidneys, while the ALKBH5 level remained stable.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!