AI Article Synopsis
- Long-term synaptic plasticity is key to understanding how lasting memories form, with significant research conducted on the marine snail Aplysia and the hippocampus in mammals.
- The work of Bliss and Lømo 30 years ago established the concept of long-term potentiation, revealing similarities in the molecular mechanisms of plasticity between Aplysia and the mammalian hippocampus.
- Recent findings on synaptic facilitation in Aplysia may provide valuable insights for future research on synaptic mechanisms in the mammalian brain.
Article Abstract
Long-term synaptic plasticity is thought to underlie many forms of long-lasting memory. Long-lasting plasticity has been most extensively studied in the marine snail Aplysia and in the mammalian hippocampus, where Bliss and Lømo first described long-term potentiation 30 years ago. The molecular mechanisms of plasticity in these two systems have proven to have many similarities. Here, we briefly describe some of these areas of overlap. We then summarize recent advances in our understanding of the mechanisms of long-lasting synaptic facilitation in Aplysia and suggest that these may prove fruitful areas for future investigation in the mammalian hippocampus and at other synapses in the mammalian brain.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1693156 | PMC |
| http://dx.doi.org/10.1098/rstb.2002.1247 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!