AI Article Synopsis
- Human fascioliasis is a growing zoonotic disease that can be mistaken for various liver diseases, making accurate diagnosis challenging.
- The traditional parasitological methods, like detecting eggs in stool or bile, are often unreliable due to issues like false negatives and immature worms.
- New immunodiagnostic tests, specifically ELISA-Fhes, showed perfect sensitivity and specificity for detecting fascioliasis, outperforming the less effective IHAT test.
Article Abstract
No doubt, human fascioliasis is an increasing worldwide zoonotic liver fluke. Clinically, human fascioliasis has to be differentially diagnosed from many hepatic diseases as acute & chronic hepatitis, schistosomiasis mansoni, visceral toxocariasis, visceral leishmaniasis, hepatic amoebiasis, biliary tract diseases and others. The parasitological diagnosis based on the demonstration of the eggs in stool, duodenal contents or bile is usually unsatisfactory due to false passage of eggs, ectopic fascioliasis, and failure of immature worm to maturation. So, ELISA-Fhes antigen (Fasciola hepatica excretory/secretory) and IHAT were evaluated in the immunodiagnosis of parasitologically proven cases of human fascioliasis compared with proven cases of human schistosomiasis mansoni and parasite-free individuals. ELISA-Fhes gave 100% sensitivity and 100% specificity. On the other hand, IHAT was less sensitive and less specific.
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Article Synopsis
- Fascioliasis is a disease mainly found in livestock but has seen an increase in human cases in Korea, linked to a green vegetable juice delivery service.
- Patients diagnosed with fascioliasis often presented with specific symptoms like eosinophilia and were treated with triclabendazole, showing varying recovery patterns in liver abscesses over time.
- MRI findings indicated that late-diagnosed patients had a higher incidence of bile duct issues, while antibody levels and eosinophil counts significantly declined after treatment, suggesting the need for ongoing monitoring.
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