AI Article Synopsis
- - C-reactive protein (CRP) levels in amniotic fluid during pregnancy have been linked to negative outcomes, but it's unclear if CRP comes from the fetus.
- - A case involved measuring CRP in fetal urine from a fetus at 15 weeks with obstructive uropathy, showing a concentration of 234 ng/mL.
- - The study concludes that fetal kidneys can produce and excrete CRP as early as 15 weeks into gestation.
Article Abstract
Background: C-reactive protein has been measured in amniotic fluid in the second and third trimesters of gestation, and its elevated concentration has been found to be associated with adverse pregnancy outcome. It remains unexplained whether amniotic fluid C-reactive protein is of fetal origin.
Case: We report the measurement of C-reactive protein in fetal urine obtained by transabdominal vescicocentesis in a fetus at 15 weeks' gestation affected by obstructive uropathy. Using an enzyme-linked immunosorbent assay, C-reactive protein was detected at a concentration of 234 ng/mL.
Conclusion: The fetal kidneys excrete C-reactive protein as early as 15 weeks' gestation.
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| http://dx.doi.org/10.1016/s0029-7844(02)02251-2 | DOI Listing |
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