AI Article Synopsis
- Interleukin-6 (IL-6) plays a crucial role in important body functions like immune response and blood cell production.
- Researchers examined the protective effects of IL-6 against skin damage caused by a chemical called DMBA in mice without IL-6.
- Results showed that the IL-6-deficient mice experienced severe skin damage, while those with IL-6 treatment showed less severe effects, highlighting IL-6's protective role.
Article Abstract
Interleukin-6 (IL-6) regulates essential physiological functions such as acute phase reaction, immune response and hematopoiesis. We here studied possible protective effects of IL-6 on skin damage caused by 7,12-dimethylbenz[a]anthracene (DMBA) by using IL-6 null mice. The mice were topically applied with a single dose of DMBA (500 microg /mouse) on the dorsal skin. Osmotic pumps filled with recombinant human IL-6 (rhIL-6) were implanted subcutaneously on the ventral side of the mice. Control mice received PBS instead of rhIL-6 by the pump. Severe skin damage was observed in IL-6-null mice, whereas only epidermal hyperplasia was observed in the wild-type mice. Recombinant hIL-6 treatment to DMBA-treated IL-6-null mice suppressed the occurrence of the skin damage, indicating.
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| http://dx.doi.org/10.1292/jvms.65.511 | DOI Listing |
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