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Artificial plasticenta: how polystyrene nanoplastics affect cultured human trophoblast cells.
Front Cell Dev Biol
February 2025
Department of Medical and Surgical Science of Infant and Adult, University of Modena and Reggio Emilia, Modena, Italy.
Background: In the human placenta, we have detected the MPs by Raman microspectroscopy analysis and, for the first time, with transmission electron microscopy. MPs fragments have been localized in different compartments of placental tissue, free in the cytoplasm and within organelles like lysosomes. Moreover, their presence has been correlated with ultrastructural alterations of some cell organelles, typical of metabolic stress, mainly dilated rough endoplasmic reticulum and numerous swollen electrodense mitochondria, as well as signs derived from involuting organelles.
View Article and Find Full Text PDFTransconjunctival correction of involutional entropion: A video demonstration.
Indian J Ophthalmol
February 2025
Department of Oculoplasty and Oncology Services (Dr. Rajendra Prasad Centre for Ophthalmic Sciences), AIIMS, New Delhi, India.
Background: Involution or aging is the most common cause of lower eyelid entropion (in-turning of eyelid margin) in the elderly population. Various pathomechanisms have been postulated for its occurrence. Aging leads to laxity of tissues and loss of muscle tone.
View Article and Find Full Text PDFLong-term ultrasonographic changes of the canine prostate gland after castration.
Front Vet Sci
January 2025
Department of Veterinary Medicine and Animal Production, University of Naples, Federico II, Naples, Italy.
Introduction: Ultrasound imaging (US) is the method of choice to assess the canine prostate gland. Whilst recent studies have documented the role of castration in the development of prostatic neoplasia, little is known about parenchymal and perfusion features of the normal and abnormal prostate in neutered dogs. No data are available concerning prostatic changes after the first 90 days following castration.
View Article and Find Full Text PDFRegression of multiple intracranial meningiomas after cessation of long-term synthetic progesterone (megestrol) medication: case report and autopsy.
Free Neuropathol
January 2024
Department of Pathology, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
Article Synopsis
- A woman developed four brain tumors (meningiomas) after 11 years of taking the synthetic progesterone drug megestrol.
- After stopping the medication at age 75, her health improved and scans showed significant tumor reduction by age 78.
- An autopsy at age 83 revealed both tumor remnants with specific hormonal receptors and fatty tissue, marking the first detailed study of this phenomenon following progestin discontinuation.
N-Pep-Zn Improves Cognitive Functions and Acute Stress Response Affected by Chronic Social Isolation in Aged Spontaneously Hypertensive Rats (SHRs).
Biomedicines
October 2024
Laboratory of Functional Biochemistry of the Nervous System, Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, 117485 Moscow, Russia.
Background/objectives: Aging and chronic stress are regarded as the most important risk factors of cognitive decline. Aged spontaneously hypertensive rats (SHRs) represent a suitable model of age-related vascular brain diseases. The aim of this study was to explore the effects of chronic isolation stress in aging SHRs on their cognitive functions and response to acute stress, as well as the influence of the chronic oral intake of N-Pep-Zn, the Zn derivative of N-PEP-12.
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