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Divergent brain solute clearance in rat models of cerebral amyloid angiopathy and Alzheimer's disease.
iScience
December 2024
Department of Anesthesiology, Yale School of Medicine, New Haven, CT 06510, USA.
Brain waste clearance from the interstitial fluid environment is challenging to measure, which has contributed to controversy regarding the significance of glymphatic transport impairment for neurodegenerative processes. Dynamic contrast enhanced MRI (DCE-MRI) with cerebrospinal fluid administration of Gd-tagged tracers is often used to assess glymphatic system function. We previously quantified glymphatic transport from DCE-MRI data utilizing regularized optimal mass transport (rOMT) analysis, however, information specific to glymphatic clearance was not directly derived.
View Article and Find Full Text PDFCerebral Hemodynamic Responses to Disease-Modifying and Curative Sickle Cell Disease Therapies.
Neurology
January 2025
From the Department of Neurology (M.A.A., W.R., A.K.S., M.J.D.), Department of Radiology and Radiological Sciences (D.M., L.T.D., L.C.J.), Division of Pediatric Neurology, Department of Pediatrics (S.M.D., L.L.M., L.C.J.), Division of Hematology and Oncology, Department of Medicine (A.A.K., M.R.D.), and Department of Psychiatry and Behavioral Sciences (M.J.D.), Vanderbilt University Medical Center, Nashville; Vanderbilt-Meharry Center of Excellence in Sickle Cell Disease (A.A.K., M.R.D.), Nashville; and Department of Electrical and Computer Engineering (M.J.D.), Vanderbilt University, Nashville, TN.
Background And Objectives: Sickle cell disease (SCD) is a hemoglobinopathy resulting in hemoglobin-S production, hemolytic anemia, and elevated stroke risk. Treatments include oral hydroxyurea, blood transfusions, and hematopoietic stem cell transplantation (HSCT). Our objective was to evaluate the neurologic relevance of these therapies by characterizing how treatment-induced changes in hemoglobin (Hb) affect brain health biomarkers.
View Article and Find Full Text PDFMRI-Based Circumferential Strain in Boys with Early Duchenne Muscular Dystrophy Cardiomyopathy.
Diagnostics (Basel)
November 2024
Department of Radiology, Stanford University, Palo Alto, CA 94305, USA.
In boys with Duchenne muscular dystrophy (DMD), cardiomyopathy has become the primary cause of death. Although both positive late gadolinium enhancement (LGE) and reduced left ventricular ejection fraction (LVEF) are late findings in a DMD cohort, LV end-systolic circumferential strain at middle wall (E) serves as a biomarker for detecting early impairment in cardiac function associated with DMD. However, E derived from cine Displacement Encoding with Stimulated Echoes (DENSE) has not been quantified in boys with DMD.
View Article and Find Full Text PDFImprove myocardial strain estimation based on deformable groupwise registration with a locally low-rank dissimilarity metric.
BMC Med Imaging
December 2024
National Engineering Research Center of Advanced Magnetic Resonance Technologies for Diagnosis and Therapy, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Background: Current mainstream cardiovascular magnetic resonance-feature tracking (CMR-FT) methods, including optical flow and pairwise registration, often suffer from the drift effect caused by accumulative tracking errors. Here, we developed a CMR-FT method based on deformable groupwise registration with a locally low-rank (LLR) dissimilarity metric to improve myocardial tracking and strain estimation accuracy.
Methods: The proposed method, Groupwise-LLR, performs feature tracking by iteratively updating the entire displacement field across all cardiac phases to minimize the sum of the patchwise signal ranks of the deformed movie.
Ultra-inert lanthanide chelates as mass tags for multiplexed bioanalysis.
Nat Commun
November 2024
Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague, Czech Republic.
Article Synopsis
- - Coordination compounds of lanthanides are crucial for biomedical uses like MRI contrast agents, but improvements in their stability and safety have been slow since the 1980s.
- - The introduction of ClickZip, a new synthetic strategy, significantly enhances the stability of these compounds, making them up to a million times more inert than previous methods, thus broadening their applications.
- - ClickZip chelates allow for efficient release and detection in biological samples, showing potential in advanced analysis techniques and specific applications in studying peptides related to cell penetration and obesity.
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