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Objective: To study the pathogenesis role of immune system activation in AIDS related Kaposi's sarcoma(AIDS-KS).
Methods: The serum levels of sFas, beta 2-microglobin, IL-10, IL-16, IL-18, IL-6 and sIL-4R were detected by ELISA in 8 AIDS-KS patients, 28 patients with HIV infection but without Kaposi's sarcoma(HIV-NKS) and 16 normal controls. The lymphocyte and their subsets, CD38(+) CD8, HLA-DR(+)CD8 in the peripheral blood mononuclear cell (PBMCs) in 12 AIDS-KS and 32 HIV-NKS were detected by flow cytometer.
Results: Beta 2-MG and sIL-4R in HIV-NKS were significantly higher than those in normal controls(P<0.05), IL-16 in HIV-NKS was significantly lower than that in controls(P<0.05). IL-18 was higher in both AIDS-KS and HIV-NKS compared with normal controls. In AIDS-KS, CD3, CD4, CD8, NK and HLA-DR(+)CD8 were lower than those in HIV-NKS whereas CD19 and CD38(+)CD8 were higher than those in HIV-NKS. But the difference was not statistically(P<0.05).
Conclusion: Although both AIDS-KS and HIV-NKS demonstrate some activation of immune system, there appears to be no significant difference between immune responses in KS and NKS patients. These data suggest that the activation of the immune system is unlikely to contribute significantly to the pathogenesis of AIDS-KS.
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http://dx.doi.org/10.3785/j.issn.1008-9292.2003.02.005 | DOI Listing |
AIDS Behav
March 2025
Center for Community Health, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, 760 Westwood Plaza, Los Angeles, CA, 90024, USA.
With the rise of technology-based interventions for HIV risk reduction among adolescents, research is needed to assess how youth participate in these strategies. We used qualitative content analysis to examine youth's posts in an online peer support intervention through the Adolescent Trials Network (ClinicalTrials.gov NCT03134833, registered May 1, 2017) for youth at higher risk of or living with HIV.
View Article and Find Full Text PDFLancet HIV
March 2025
Department of Medicine, University of Illinois Chicago, Chicago, IL, USA.
Background: Long-acting formulations of HIV pre-exposure prophylaxis (PrEP) appear particularly well suited to adolescents. We aimed to establish the safety, tolerability, and acceptability of long-acting injectable cabotegravir as PrEP in cisgender adolescent girls.
Methods: HPTN 084-01 is a single-arm, open-label, phase 2b trial conducted at three clinical research sites in South Africa, Uganda, and Zimbabwe.
Arch Orthop Trauma Surg
March 2025
Department for Orthopaedics and Trauma Surgery, Musculoskeletal University Center Munich (MUM), University Hospital, LMU Munich, Marchioninistrasse 15, Munich, 81377, Germany.
Background: Wearable activity sensors offer valuable insights into physical activity and are increasingly used in clinical and rehabilitation settings. However, most are designed for healthy individuals, necessitating a thorough evaluation of their applicability for pathological gait patterns. This study aims to assess the accuracy of commercially available wearables in measuring gait patterns among patients with lower limb injuries compared to healthy individuals.
View Article and Find Full Text PDFCancer Immunol Immunother
March 2025
School of Acupuncture and Tuina, Shandong University of Traditional Chinese, Medicine, Jinan, 250013, People's Republic of China.
The TAM receptor family is getting more and more attention in the field of tumour immunity. Activation of TAM receptors not only aids in the survival and multiplication of tumour cells but also increases their likelihood of invading other cells and spreading. In addition, activation of TAM receptors helps to inhibit the anti-tumour immune response, allowing tumour cells to evade immune surveillance.
View Article and Find Full Text PDFChemSusChem
March 2025
Tianjin University, School of Materials Science and Engineering, Weijin Road 92, 300072, China, CHINA.
Industrial water-alkali splitting is facing high energy consumption due to the high overpotential of commercial Ni mesh anode in oxygen evolution reaction (OER) processing. Herein, a simple ball-milling-assisted laser scanning strategy was employed to introduce the hardest Lewis acid chromium (Cr) into the Ni matrix to form Cr2Ni3 catalysts supported by Ni mesh, endowing such NiCr/Ni mesh anode a robust OER performance at a low-cost. It is shown that facilitating the self-adsorption of oxygen species and promoting the leaching of soluble Cr cations aids in reconstructing Ni cations into active (oxy)hydroxide species.
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