The effectiveness of galactomannan detection with the Platelia test was evaluated in a prospective study of 3,327 sera from 807 patients. The specificity was 99.6% (748 of 751 cases). For the groups of patients with proven and probable invasive aspergillosis, the sensitivity was 50.0% (17 of 34 cases). The disappointing sensitivity associated with the presence of rare false-positive cases underlines the limits of this test.
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http://dx.doi.org/10.1128/JCM.41.5.2184-2186.2003 | DOI Listing |
J Fungi (Basel)
November 2024
Clinical Microbiology and Virology Unit, Azienda USL di Piacenza, 29121 Piacenza, Italy.
The analytical performance of the new Galactomannan Ag VirCLIA mono-test (Vircell S.L.) was compared to the Platelia™ Ag ELISA assay (Bio-Rad).
View Article and Find Full Text PDFMed Mycol
November 2024
Oniris, VetAgroBio Nantes, 44300 Nantes, France.
Aspergillosis remains a common and life-threatening disease in captive and wild birds all over the world. The diagnosis is currently based on clinical signs or lesions, diagnostic imaging, and a variety of biological tests. This systematic review aimed to compare the accuracy of antemortem diagnostic tests for Aspergillus infection in birds.
View Article and Find Full Text PDFJ Fungi (Basel)
September 2024
Haematological Department, Centre Hospitalier Universitaire (CHU) Université Catholique de Louvain (UCL) Namur Site Godinne, 5530 Yvoir, Belgium.
Background: Invasive aspergillosis (IA) is a significant cause of morbidity and mortality in patients with haematological malignancies. Accurate diagnosis of IA is challenging due to non-specific symptoms and the impact of antifungal prophylaxis on biomarker sensitivity.
Methods: This retrospective study evaluated the diagnostic performance of three serum biomarkers: Galactomannan Ag VirClia Monotest (VirClia), Wako β-D-Glucan Test (Wako BDG), and MycoGENIE Real-Time PCR (MycoGENIE PCR).
Med Mycol J
September 2024
Department of Respiratory Medicine and Infectious Diseases, Niigata University Medical & Dental Hospital.
Mycoses
August 2024
Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brazil.
During the COVID-19 pandemic, many patients in intensive care units (ICUs) were affected by invasive fungal infections, including aspergillosis, contributing to a high mortality rate. Diagnosing proven COVID-19-associated pulmonary aspergillosis (CAPA) requires clinical and radiological evaluations, along with laboratory testing of bronchoalveolar lavage samples or lung biopsies. However, these procedures and equipment are often inaccessible in developing countries or regions with limited resources, including Brazil.
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