AI Article Synopsis
- Angiotensin II is crucial in heart failure post-acute myocardial infarction (AMI), with a focus on the role of AT2 receptors in this process.
- AT2 receptors show increased presence in heart tissue after AMI, and mice lacking these receptors had significantly lower survival rates and worsened symptoms compared to normal mice.
- The study suggests that AT2 receptors could provide protective effects for the heart following an AMI event.
Article Abstract
Background: Angiotensin II plays a prominent role in the progression of heart failure after acute myocardial infarction (AMI). Although both angiotensin type 1 (AT1) and type 2 (AT2) receptors are known to be present in the heart, comparatively little is known about the latter. We therefore examined the role played by AT2 receptors in post-AMI heart failure.
Methods And Results: In wild-type mice subjected to AMI by coronary artery ligation, AT2 receptor immunoreactivity is upregulated in the infarct and border areas. Among AT2 receptor-null (-/-) mice, the 7-day survival rate after AMI was significantly lower than among wild-type mice (43% versus 67%; P<0.05). All sham-operated animals of both genotypes survived through the study. Ventricular mRNA levels for brain natriuretic peptide were elevated in both genotypes 24 hours after coronary occlusion, with levels in AT2-/- significantly higher than in wild-type mice, as were their lung weights, and histological examination revealed marked pulmonary congestion in the AT2-/- mice. Cardiac function was significantly decreased in AT2-/- mice 2 days after AMI.
Conclusions: AT2 receptor deficiency exacerbates short-term death rates and heart failure after experimental AMI in mice. The AT2 receptor may thus exert a protective effect on the heart after AMI.
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| http://dx.doi.org/10.1161/01.CIR.0000072763.98069.B4 | DOI Listing |
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