Microarrays provide a powerful new tool for understanding the regulation of gene expression in bacteria. Many recent publications have used microarrays for identifying regulon members and stimulons that describe the complex organismal responses to environmental perturbations. The use of bioinformatics to identify DNA binding sites of transcription factors greatly facilitates the interpretation of these experiments. Understanding the transcriptome of an organism includes identifying all transcripts and mapping their 5' and 3' ends. High-density oligonucleotide arrays have enabled the identification of many new transcripts, including small RNAs and antisense RNAs.
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http://dx.doi.org/10.1016/s1369-5274(03)00034-1 | DOI Listing |
Appl Immunohistochem Mol Morphol
November 2024
Department of Pathology, NordiQC, Aalborg University Hospital.
Accurate diagnosis of cancer of unknown primary (CUP) poses a significant daily challenge for pathologists, necessitating reliable immunohistochemical (IHC) markers. SATB2 is a transcription factor primarily expressed in colorectal neoplasms. This study investigates the IHC expression of SATB2 in malignant melanomas (MM).
View Article and Find Full Text PDFVirchows Arch
November 2024
Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany.
J Leukoc Biol
November 2024
Division of Allergy and Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, 240 East Huron Street, Chicago, IL 60611, United States.
Eosinophils are granulocytes that can accumulate in increased numbers in tissues and/or peripheral blood in disease. Phenotyping of eosinophils in health and disease has the potential to improve the precision of diagnosis and choice of therapies for eosinophilic-associated diseases. Transcriptional profiling of eosinophils has been plagued by cell fragility and difficulty isolating high-quality RNA.
View Article and Find Full Text PDFEur J Hum Genet
July 2024
Montpellier University, Laboratory of Cytogenomics, University Hospital of Montpellier, Montpellier, France.
Plant Genome
June 2024
SuSTATability Statistical Solutions, Melbourne, Victoria, Australia.
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