The presence of microorganisms in certain renal calculi having been demonstrated; currently, there is a debate about the possibility of certain germs of extremely small size, Nanobacteria, which can have an important role in the general theory of lithogenesis.
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Arch Med Sci Atheroscler Dis
January 2024
1 Affiliated Hospital, Jiangxi Medical College, Nanchang University, China.
Introduction: The aim of the study was to study the role of nanobacteria in the formation of renal calculi and the underlying mechanism.
Material And Methods: A total of 90 clean Wistar male rats were randomly divided into a negative control group, an experimental group, and an interference group. From the end of the first week of modelling, 10 consecutive times once a week, 3 rats in each group were randomly selected to measure the biochemical blood markers and urine metabolism.
Int J Mol Med
August 2021
Department of Urology, People's Hospital of Longhua, Southern Medical University, Shenzhen, Guangdong 518109, P.R. China.
Kidney stone disease is one of the oldest diseases known to medicine; however, the mechanisms of stone formation and development remain largely unclear. Over the past decades, a variety of theories and strategies have been developed and utilized in the surgical management of kidney stones, as a result of recent technological advances. Observations from the authors and other research groups suggest that there are five entirely different main mechanisms for kidney stone formation.
View Article and Find Full Text PDFSci Rep
November 2020
Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo, 153-8902, Japan.
Dietary phosphate overload induces chronic kidney disease (CKD), and calciprotein particles (CPPs), a form of nanoparticle comprising calcium phosphate and serum proteins, has been proposed to cause renal toxicity. However, the mechanism of CPP cytotoxicity in renal tubular cells is unknown. Here we show that in renal proximal tubular epithelial HK-2 cells, endocytosed CPPs accumulate in late endosomes/lysosomes (LELs) and increase their luminal pH by ~ 1.
View Article and Find Full Text PDFUrologe A
November 2019
Abteilung für Urologie und Kinderurologie, Krankenhaus der Barmherzigen Brüder Trier, Nordallee 1, 54292, Trier, Deutschland.
The process of kidney stone formation is complex and still not completely understood. Supersaturation and crystallization are the main drivers for the etiopathogenesis of uric acid, xanthine and cystine stones but this physicochemical concept fails to adequately explain the formation of calcium-based nephrolithiasis, which represents the majority of kidney stones. Contemporary concepts of the pathogenesis of calcium-based nephrolithiasis focus on a nidus-associated stone formation of calcium-based nephrolithiasis on Randall's plaques or on plugs of Bellini's duct.
View Article and Find Full Text PDFMicrob Pathog
January 2019
Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
The use of nanotechnology for nanobacteria (or calcifying nanoparticles) treatment is a new creative approach. Use of selenium nanoparticles (SeNPs) as anti-nanobacterial agents might be considered as a bright promising approach due to their critical role in the inhibition of crystal growth and aggregation of calcium oxalate. Hence, in this study, we investigated the probable outcome of SeNPs inhibitory effects on growth of nanobacteria.
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