Objectives: Research on disability and active life expectancy (ALE) has often criticized the measurement of disability but has rarely empirically investigated the effect of changing measurement. The purpose of this study was to determine whether altering the number of activities of daily living (ADLs) required to consider an individual "disabled" affects population-based ALE estimates after considering parametric uncertainty and sampling error.
Methods: The authors develop a Bayesian approach to estimating multistate life tables for a three-dimensional state space, using data on community-dwelling older adults from the 1989 and 1994 National Long Term Care Survey analytic files. Empirical confidence intervals for ALE are compared across 6 models using successively higher ADL cutoffs for defining individuals as being disabled.
Results: After considering sampling and other errors in the estimation of transition probabilities, the authors found that altering the threshold for measuring disability has relatively little effect on ALE estimates, especially with higher ADL-level thresholds and at older ages.
Discussion: The implications of the results include that disability measurement, including altering the definition of being disabled and possibly expanding the state space of a model, may not affect population-based estimates of ALE.
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http://dx.doi.org/10.1093/geronb/58.3.s171 | DOI Listing |
J Intellect Dev Disabil
December 2021
School of Nursing, Midwifery and Social Work, The University of Queensland, St Lucia, Queensland, Australia.
The study reported here investigated the views of staff who worked with adults with intellectual disability regarding the likely future of such adults. Staff were provided with a short vignette portraying an adult with intellectual disability and asked to describe that individual's future in five years and then to indicate the likelihood of the individual's participation in aspects of adult life reflecting life as typically experienced by age peers in the general population. Responses suggested that staff did not expect the adults with intellectual disability to have the same experiences as their peers, although responses to direct questions about participation were more positive than those to the vignette.
View Article and Find Full Text PDFJ Intellect Dev Disabil
December 2022
Cybersafety Professorship of Applied Sciences, NHL Stenden University of Applied Sciences, Leeuwarden, Netherlands.
Background: This study reports the findings from a Dutch study, exploring care workers' knowledge and perceptions of the online lives of adolescents with mild or borderline intellectual disabilities.
Method: Using an inductive research design 33 semi-structured interviews were conducted with care workers.
Results: Three themes were derived from the data: (1) The clients' online world is largely unknown to care workers.
J Intellect Dev Disabil
September 2021
School of Curriculum and Pedagogy and Director of The Marie Clay Research Centre-LEAD in Early Literacy, Faculty of Education and Social Work, University of Auckland, Auckland, New Zealand.
Background: This study investigated transition, or school leaving, as experienced by young adults living in Aotearoa New Zealand who had significant intellectual and developmental disabilities.
Method: To investigate these typically unheard perspectives, qualitative methods were adapted to individual communication preferences. Personal and contextual intersections were critically analysed using the theoretical framework of the capability approach.
Urol Oncol
January 2025
Vita-Salute San Raffaele University and IRCCS San Raffaele Hospital, Milan, Italy; Department of Medical Oncology, IRCCS San Raffaele University, Milan, Italy.
Treatment options for recurrent high-risk non-muscle-invasive bladder cancer (HR NMIBC) and muscle-invasive bladder cancer (MIBC) are limited, highlighting a need for clinically effective, accessible, and better-tolerated alternatives. In this review we examine the clinical development program of TAR-200, a novel targeted releasing system designed to provide sustained intravesical delivery of gemcitabine to address the needs of patients with NMIBC and of those with MIBC. We describe the concept and design of TAR-200 and the clinical development of this gemcitabine intravesical system in the SunRISe portfolio of studies.
View Article and Find Full Text PDFAdv Clin Chem
January 2025
School of Biosystem and Biomedical Science, College of Health Science, Korea University, Seoul, Republic of Korea; Department of Integrated Biomedical and Life Science, Korea University, Seoul, Republic of Korea; BK21FOUR R&E Center for Learning Health Systems, Korea University, Seoul, Republic of Korea; L-HOPE Program for Community-Based Total Learning Health Systems, Korea University, Seoul, Republic of Korea. Electronic address:
The advent of multiomics has ushered in a new era of cancer research characterized by integrated genomic, transcriptomic and proteomic analysis to unravel the complexities of cancer biology and facilitate the discovery of novel biomarkers. This chapter provides a comprehensive overview of the concept of multiomics, detailing the significant advances in the underlying technologies and their contributions to our understanding of cancer. It delves into the evolution of genomics and transcriptomics, breakthroughs in proteomics, and overarching progress in multiomic methodologies, highlighting their collective impact on cancer biomarker discovery.
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