Regulatory inactivation of DnaA helps ensure that the Escherichia coli chromosome is replicated only once per cell cycle, through accelerated hydrolysis of active replication initiator ATP-DnaA to inactive ADP-DnaA. Analysis of deltahda strains revealed that the regulatory inactivation of DnaA component Hda is necessary for maintaining controlled initiation but not for cell growth or viability.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC154069 | PMC |
| http://dx.doi.org/10.1128/JB.185.10.3244-3248.2003 | DOI Listing |
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