Substituted bridged phenyl piperidines: orally active growth hormone secretagogues.

Bioorg Med Chem Lett

Department of Medicinal Chemistry, Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA.

Published: May 2003

A new series of growth hormone secretagogues have been discovered. The best compound, 26j, shows excellent ability to release growth hormone both in vitro and in vivo. The synthesis and biological activity of these compounds are discussed.

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http://dx.doi.org/10.1016/s0960-894x(03)00261-0DOI Listing

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