The synthesis and activity of novel benzothiophene derivatives are described. In the t-Pa-induced fibrin clot lysis assay, several compounds inhibit the formation of the tPa-PAI-1 complex with submicromolar IC(50). This class of compounds potentially represents a new generation of antithrombotic-fibrinolytic agents.
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Theoretical insights into fluorescent properties and ESIPT behavior of novel flavone-based fluorophore and its thiol and thione derivatives.
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December 2024
Department of Chemistry and Material Science, College of Science, Nanjing Forestry University, Nanjing 210037, People's Republic of China. Electronic address:
For the typical ESIPT process, the proton transfer process is often completed via the intramolecular hydrogen bond (IHB) with oxygen or nitrogen as proton donor or proton acceptor. In recent years, the ESIPT process for sulfur-containing hydrogen bonds has received more and more attention, but it has been rarely reported. We systematically studied the ESIPT processes and photophysical properties of 2-(benzothiophene-2-yl)-3-hydroxy-4H-chromen-4-one (BTOH), 2-(benzothiophene-2-yl)-3-mercapto-4H-chromen-4-one (BTSH) and 2-(benzothiophen-2-yl)-3-hydroxy-4H-chromene-4-thione (BTS) at the HISSbPBE/6-31+G(d,p) and TD-HISSbPBE/6-31+G(d,p) computational level.
View Article and Find Full Text PDFSynthesis of Aminated C-3 Aryloylated Benzofuran, Furopyridine, Benzothiophene, and Indole Derivatives from 1,6-Enyne and -Aminopyridinium Salt in Visible Light.
J Org Chem
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Department of Chemistry, Indian Institute of Technology Delhi, New Delhi 110016, India.
We report a visible-light-assisted tandem oxidative 5--dig cyclization of 1,6-enynes for the synthesis of aminated C-3 aryloylated benzofuran, furopyridine, benzothiophene, and indole derivatives. The nitrogen-centered radical generated in situ from -aminopyridinium salt initiates the consecutive formation of C-N, C-C, and C-O bonds. The methodology exhibits good functional group tolerance and regioselectivity, furnishing products in good to excellent yields at room temperature.
View Article and Find Full Text PDFMast Cells Contribute to Pressure Overload-Induced Myocardial Hypertrophy by Upregulating TRPV4 via Histamine: Role of Ca2+/ CnA/NFATc3 Signaling Pathway.
Curr Med Sci
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Department of Cardiovasology, Affiliated Renhe Hospital of China Three Gorges University, Yichang, 443002, China.
Objective: To investigate whether cardiac mast cells (MCs) participate in pressure overload-induced myocardial hypertrophy through the regulation of transient receptor potential vanilloid 4 (TRPV4).
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Ag(i) emitters with ultrafast spin-flip dynamics for high-efficiency electroluminescence.
Chem Sci
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College of Chemistry and Molecular Sciences, Hubei Key Laboratory on Organic and Polymeric Optoelectronic Materials, Wuhan University Wuhan 430072 China
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Institute for Electronics Microelectronics and Nanotechnology (IEMN), CNRS, Av. Poincaré, Villeneuve d'Ascq 59652, France.
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