A joint analysis of five paternal half-sib Holstein families that were part of two different granddaughter designs (ADR- or Inra-design) was carried out for five milk production traits and somatic cell score in order to conduct a QTL confirmation study and to increase the experimental power. Data were exchanged in a coded and standardised form. The combined data set (JOINT-design) consisted of on average 231 sires per grandsire. Genetic maps were calculated for 133 markers distributed over nine chromosomes. QTL analyses were performed separately for each design and each trait. The results revealed QTL for milk production on chromosome 14, for milk yield on chromosome 5, and for fat content on chromosome 19 in both the ADR- and the Inra-design (confirmed within this study). Some QTL could only be mapped in either the ADR- or in the Inra-design (not confirmed within this study). Additional QTL previously undetected in the single designs were mapped in the JOINT-design for fat yield (chromosome 19 and 26), protein yield (chromosome 26), protein content (chromosome 5), and somatic cell score (chromosome 2 and 19) with genomewide significance. This study demonstrated the potential benefits of a combined analysis of data from different granddaughter designs.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2732702 | PMC |
| http://dx.doi.org/10.1186/1297-9686-35-3-319 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effects of maternal taxane chemotherapy exposure on daughters' ovarian reserve and fertility potential.
F S Sci
May 2024
Department of Obstetrics and Gynecology, Warren Alpert Medical School of Brown University, Providence, Rhode Island; Department of Obstetrics and Gynecology, Program in Women's Oncology, Women and Infants Hospital of Rhode Island, Providence, Rhode Island. Electronic address:
Article Synopsis
- The study aims to investigate the long-term reproductive effects on female offspring exposed to taxanes (docetaxel and paclitaxel) in utero, focusing on their ovarian reserve and fertility potential.
- Pregnant mice were administered either saline, docetaxel, or paclitaxel, and their daughters were later analyzed for ovarian health, hormone levels, and reproductive outcomes.
- Results show that in utero taxane exposure leads to ovarian toxicity in the daughters, characterized by increased follicular abnormalities and alterations in hormone levels, which could impact their fertility.
A Familial Case of Multiple Endocrine Neoplasia 2A: From Morphology to Genetic Alterations Penetration in Three Generations of a Family.
Diagnostics (Basel)
March 2023
Pathology Department, Beijing Tongren Hospital, Capital Medical University, Beijing Key Laboratory of Head and Neck Molecular Diagnostic Pathology, Beijing 100730, China.
This paper illustrates a rare syndrome of multiple endocrine neoplasia type 2A (MEN2A) in a family of three generations. In our case, the father, son and one daughter developed phaeochromocytoma (PHEO) and medullary thyroid carcinoma (MTC) over a period of 35 years. Because of the metachronous onset of the disease and lack of digital medical records in the past, the syndrome was not found until a recent fine needle aspiration of an MTC-metastasized lymph node from the son.
View Article and Find Full Text PDFGrowing Older in the Shadow of Childhood Intrafamilial Sexual Abuse: Women's Reflections on Parenthood Experiences Throughout the Life Course.
Gerontologist
February 2022
Department of Criminology, Ariel University, Ariel, Israel.
Background And Objectives: The long-term effect of intrafamilial sexual abuse for the survivors' parenting rarely focuses on older women who are mothers of adult children. The aim of this study was to explore the parenthood experiences of aging women survivors of intrafamilial sexual abuse, using the life course perspective as a conceptual framework.
Research Design And Methods: Interpretive phenomenological analysis was used to analyze the narratives of 19 older women survivors of intrafamilial sexual abuse.
Maternal Consumption of a Diet Rich in Maillard Reaction Products Accelerates Neurodevelopment in F1 and Sex-Dependently Affects Behavioral Phenotype in F2 Rat Offspring.
Foods
May 2019
Institute of Molecular Biomedicine, Medical Faculty, Comenius University, 81108 Bratislava, Slovakia.
Thermal processing of foods at temperatures > 100 °C introduces considerable amounts of advanced glycation end-products (AGEs) into the diet. Maternal dietary exposure might affect the offspring early development and behavioral phenotype in later life. In a rat model, we examined the influence of maternal (F0) dietary challenge with AGEs-rich diet (AGE-RD) during puberty, pregnancy and lactation on early development, a manifestation of physiological reflexes, and behavioral phenotype of F1 and F2 offspring.
View Article and Find Full Text PDFDetermination of quantitative trait nucleotides by concordance analysis between quantitative trait loci and marker genotypes of US Holsteins.
J Dairy Sci
October 2018
USDA, Agricultural Research Service, Animal Genomics and Improvement Laboratory, Beltsville, MD 20705-2350.
Experimental designs that exploit family information can provide substantial predictive power in quantitative trait nucleotide discovery projects. Concordance between quantitative trait locus genotype as determined by the a posteriori granddaughter design and marker genotype was determined for 30 trait-by-chromosomal segment effects segregating in the US Holstein population with probabilities of <10 to accept the null hypotheses of no segregating gene affecting the trait within the chromosomal segment. Genotypes for 83 grandsires and 17,217 sons were determined by either complete sequence or imputation for 3,148,506 polymorphisms across the entire genome; 471 Holstein bulls had a complete genome sequence, including 64 of the grandsires.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!