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The Influence of L. Extract and Ellagic Acid on Oxidative Stress, Inflammation, and Bone Regeneration Biomarkers.
Int J Mol Sci
November 2024
Department of Preclinical Discipline, Faculty of Medicine and Pharmacy, University of Oradea, 10, 1 December Square, 410073 Oradea, Romania.
Bone regeneration is a highly dynamic and complex process that involves hematopoietic stem cells and mesenchymal cells, collagen fibers, non-collagenous proteins and biomolecules from extracellular matrices, and different cytokines and immune cells, as well as growth factors and hormones. Some phytochemicals due to antioxidant and anti-inflammatory effects can modulate the bone signaling pathways and improve bone healing and thus can be a good candidate for osteoregeneration. The aim of this study was to analyze the impact of L.
View Article and Find Full Text PDFPediatric double-seropositive anti-glomerular basement membrane antibody disease: A case report and literature review.
Clin Nephrol Case Stud
November 2024
Department of Pediatrics, Cheikh Khalifa International University Hospital, Faculty of Medicine, Mohammed VI University of Health Sciences (UM6SS), Casablanca, Morocco.
Introduction: Glomerular basement membrane (GBM) disease is a severe and exceedingly rare disorder characterized by the presence of circulating antibodies targeting the non-collagen NC1 domain of the α3 chain of collagen type IV in glomerular and alveolar basement membranes. It typically presents as rapidly progressive glomerulonephritis (RPGN), often accompanied by pulmonary hemorrhage. The occurrence of double-seropositivity for anti-GBM antibody and anti-neutrophil cytoplasmic antibody (ANCA), primarily with myeloperoxidase specificity (MPO-ANCA), is particularly uncommon in pediatric cases.
View Article and Find Full Text PDFReactivity against the BP180 ectodomain in patients with bullous pemphigoid, mucous membrane pemphigoid, multiple sclerosis and Parkinson disease.
Exp Dermatol
July 2024
Lübeck Institute of Experimental Dermatology (LIED), University of Lübeck, Lübeck, Germany.
Article Synopsis
- The main part of BP180 that causes problems in certain skin diseases, like bullous pemphigoid (BP) and mucous membrane pemphigoid (MMP), is called NC16A, which is attacked by autoantibodies.
- Most tests can find these autoantibodies in BP patients (80-90%), but only half of MMP patients have them.
- This study discovered other parts of BP180 that can also be recognized by autoantibodies, which could help in creating better tests for people who don’t have the NC16A antibodies.
Cardiovascular Magnetic Resonance Radiomics to Identify Components of the Extracellular Matrix in Dilated Cardiomyopathy.
Circulation
July 2024
Departments of Medicine (S. Nakamori, A.A., A.S.F., L.H.N., W.J.M., R.N.), Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA.
Article Synopsis
- The study aimed to see if cardiovascular magnetic resonance radiomics can differentiate between noncollagen and inflammatory extracellular space from collagen in patients with dilated cardiomyopathy.
- Researchers analyzed data from 132 patients who had undergone heart imaging and a biopsy, calculating various radiomic features and using principal component analysis to narrow them down for better diagnostic accuracy.
- Results showed four distinct histopathological groups, revealing that noncollagenous extracellular space expansion had the strongest link to myocardial inflammation, and using radiomics improved the differentiation between types of extracellular space compared to traditional imaging methods.
Bone collagen tensile properties of the aging human proximal femur.
Bone Rep
June 2024
ARTORG Center for Biomedical Engineering Research, University of Bern, Switzerland.
Despite the dominant role of bone mass in osteoporotic fractures, aging bone tissue properties must be thoroughly understood to improve osteoporosis management. In this context, collagen content and integrity are considered important factors, although limited research has been conducted on the tensile behavior of demineralized compact bone in relation to its porosity and elastic properties in the native mineralized state. Therefore, this study aims (i) at examining the age-dependency of mineralized bone and collagen micromechanical properties; (ii) to test whether, and if so to which extent, collagen properties contribute to mineralized bone mechanical properties.
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