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Colon-targeted engineered postbiotics nanoparticles alleviate osteoporosis through the gut-bone axis.
Nat Commun
December 2024
Department of Orthodontics, Peking University School and Hospital of Stomatology, Beijing, China.
The potential for mitigating intestinal inflammation through the gut-bone axis in the treatment of osteoporosis is significant. While various gut-derived postbiotics or bacterial metabolites have been created as dietary supplements to prevent or reverse bone loss, their efficacy and safety still need improvement. Herein, a colon-targeted drug delivery system is developed using surface engineering of polyvinyl butyrate nanoparticles by shellac resin to achieve sustained release of postbiotics butyric acid at the colorectal site.
View Article and Find Full Text PDFMechanisms of gut homeostasis regulating Th17/Treg cell balance in PMOP.
Front Immunol
December 2024
Gansu University of Traditional Chinese Medicine, Lanzhou, China.
Postmenopausal osteoporosis (PMOP) is a metabolic bone disease driven by estrogen deficiency, primarily manifesting as reduced bone mass and heightened fracture risk. Its development is intricately linked to the balance between Th17 and Treg cells. Recent studies have highlighted the significant role of gut homeostasis in PMOP.
View Article and Find Full Text PDFCorrigendum to 'Osteostaticytes: A novel osteoclast subset couples bone resorption and bone formation'[Journal of Orthopaedic Translation 47 (2024) 144-160].
J Orthop Translat
November 2024
Department of Orthopedics, The First Affiliated Hospital of Third Military Medical University (Army Medical University), Chongqing, PR China.
Article Synopsis
- The article DOI: 10.1016/j.jot.2024.06.010 has been corrected for accuracy.
- This correction ensures that readers are accessing the most reliable information.
- It reflects ongoing efforts to maintain academic integrity and clarity in published research.
Differential Regulatory Effects of Probiotics on Bone Metabolism by the Status of Bone Health and Delivery Route.
Probiotics Antimicrob Proteins
December 2024
Department of Oral Microbiology and Immunology, and Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Republic of Korea.
Probiotics are known to have favorable effects on human health. Nevertheless, probiotics are not always beneficial and can cause unintended adverse effects such as bacteremia and/or inflammation in immunocompromised patients. In the present study, we investigated the effects of probiotics on the regulation of bone metabolism under different health conditions and delivery routes.
View Article and Find Full Text PDFExploring the Effects of Zingerone on Differentiation and Signalling Pathways in Bone Cell Lines.
Metabolites
December 2024
Department of Physiology, School of Medicine, Faculty of Health Sciences, University of Pretoria, Private Bag X323, Gezina, Pretoria 0031, South Africa.
Objective: Ensuring adequate bone health is crucial for preventing conditions such as osteoporosis and fractures. Zingerone, a phytonutrient isolated from cooked ginger, has gained attention for its potential benefits in bone health. This study evaluated the osteoprotective potential of zingerone and its effects on differentiation and signalling pathways using SAOS-2 osteosarcoma and RAW264.
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