In this study we examined the immunohistochemical localization of sex steroid receptors for estrogen alpha (ER alpha) and ER beta, progesterone-A (PR-A) and PR-B, and androgen (AR) in human thymoma (n = 132) and correlated these findings with various clinicopathological parameters. We used RT-PCR and real-time PCR to further study the expression of these receptors in 20 thymoma cases. Immunoreactivity for all sex steroid receptors was detected in the nuclei of thymoma epithelial cells. The percentage of immunopositive cases and the H-score values for each receptor (mean +/- SD) were: ER alpha, 66% and 85.8 +/- 80.2; ER beta, 7% and 7.2 +/- 8.7; PR-A, 4% and 2.7 +/- 4.9; PR-B, 49% and 55.8 +/- 68.3; and AR, 15% and 14.1 +/- 11.7, respectively. The results of real-time PCR were consistent with those of immunohistochemistry, especially results for ER alpha, PR-B, and AR. A significant positive correlation was detected between immunoreactivity for ER alpha and PR-B. ER alpha immunoreactivity was inversely correlated with tumor size, clinical stage, WHO classification, and Ki-67 labeling index. In addition, the status of ER alpha immunoreactivity was significantly associated with a better clinical outcome in thymoma patients. Results from our study suggest that estrogens may inhibit thymoma growth via ER alpha, and that ER alpha immunoreactivity may act as a prognostic factor in human thymoma.
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http://dx.doi.org/10.1210/jc.2002-021353 | DOI Listing |
Cell Rep
March 2025
Laboratory of Molecular Neurobiology, Graduate School of Biostudies, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan; Department of Molecular Endocrinology, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan; AMED-CREST, Japan Agency for Medical Research and Development, Chiyoda-ku, Tokyo 100-0004, Japan; Department of Moonshot Research and Development Program, Japan Science and Technology Agency, Chiyoda-ku, Tokyo 102-0076, Japan. Electronic address:
Sex steroid hormones such as progesterone play a pivotal role in reproductive functions and maintaining pregnancy; however, the impact of progesterone on the interaction between mother and embryo is unclear. Here, we demonstrate that the relationship between maternal progesterone and membrane progesterone receptor epsilon (mPRε) in adipose tissue regulates embryonic nutritional environment and growth after birth in mice. The activation of adipose mPRε by increased progesterone during pregnancy enhances maternal insulin resistance via prostaglandin production, efficiently providing glucose to embryos.
View Article and Find Full Text PDFFa Yi Xue Za Zhi
December 2024
Shanghai Key Laboratory of Forensic Medicine, Key Laboratory of Forensic Science, Ministry of Justice, Shanghai Forensic Service Platform, Academy of Forensic Science, Shanghai 200063, China.
Anabolic androgenic steroids (AASs) are a class of synthetic steroid hormones that mimic androgens, and they rank as the most widely abused doping agents worldwide. High resolution mass spectrometry (HRMS) has unique advantages in the detection of AASs due to its high resolution, high sensitivity, high selectivity and data traceability. HRMS can not only be used for the qualitative and quantitative analysis of AASs and their metabolites in different biological samples, effectively improving the ability to analyze complex samples and increasing the reliability of analytical results, but can also infer AASs metabolites and reveal metabolic pathways by combining and metabolic models.
View Article and Find Full Text PDFBirth Defects Res
March 2025
School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.
Introduction: Hormone pregnancy tests (HPTs), containing synthetic progesterone and oestrogen, were used to diagnose pregnancy in the 1950s to early 1980s. An existing pregnancy was purported to be unaffected while expulsion of the uterine lining (withdrawal bleed) was supposed to occur if the woman was not pregnant. However, studies in the 1960s-1980s associated HPTs with teratogenicity and some countries banned their use in the early 1970s.
View Article and Find Full Text PDFSci Rep
March 2025
Department of Zoology, Institute of Science, Banaras Hindu University, Varanasi, 221005, India.
Polycystic ovary syndrome (PCOS) is the most common cause of infertility in reproductive-age women, and its etiology and exact treatment are not yet established. Adropin is a unique hepatokine involved in maintaining energy homeostasis, and its level has been reported to decline in serum and follicular fluid of PCOS women. Thus, present study was designed to investigate the effect of adropin on hormonal and reproductive abnormalities in PCOS mice.
View Article and Find Full Text PDFIntroduction: The role of female sex hormones and their influence on asthma's development and natural history remain uncertain. Our study aims to enhance understanding of exogenous sex hormones' role in asthma development and manifestation, considering phenotypic heterogeneity and focusing on metabolic syndrome-linked asthma that has shown increased severity in females.
Methods And Analysis: A cohort study using primary care data from the Clinical Practice Research Datalink (CPRD) databases linked with additional data sources (Hospital Episode Statistics, ethnicity and deprivation) will include individuals aged 16-70 years, spanning 1 January 2005 to 31 December 2019.
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