Background: Management of blunt liver injury is predominantly nonoperative. However, complications occur in 10% to 25% of patients, with half taking place more than 24 hours after injury. Few reports have addressed the management of the new pattern of these delayed complications, which is the objective of this study.
Methods: Adult patients admitted to our level one trauma center from 1995 to 2000 with blunt liver injury were identified. Demographic, physiologic and laboratory data, computed tomography (CT) and operative findings, and complications were reviewed.
Results: Blunt liver injury was identified in 192 patients. Thirty-nine patients (20%) underwent immediate celiotomy. The remaining 153 patients were initially managed nonoperatively. Liver-related complications developed in 19 (12%) patients. Fifteen patients underwent delayed celiotomy to treat secondary inflammatory processes, from bile leak (6), hemorrhage (5), and hepatic abscess (1), and to treat abdominal compartment syndrome (2), and decompress hepatic compartment syndrome (1). Although no deaths or complications were directly caused by delayed celiotomy, 2 deaths (11%), occurring early in this series, were attributed to liver-related complications.
Conclusions: These complications, occurring in 12% of patients with liver injuries, may be a consequence of initial nonoperative management. Although these findings do not negate nonoperative management of blunt liver injury, this approach can be hazardous and requires diligence to recognize and treat delayed and potentially fatal complications.
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http://dx.doi.org/10.1016/s0002-9610(03)00046-1 | DOI Listing |
Exp Clin Transplant
December 2024
>From the Jacobs School of Medicine and Biomedical Sciences, Buffalo, New York, USA.
Objectives: The risks of mortality and graft failure in those receiving organ transplants from donors who have drowned are unclear. We compared 5-year mortality and graft survival from those receiving a drowned donor kidney or liver to those receiving organs from alternative causes of nondrowning donor death.
Materials And Methods: In this retrospective analysis, we searched the United Network for Organ Sharing database between January 1, 2010, and June 30, 2022.
BMC Genomics
January 2025
College of Fisheries, Huazhong Agricultural University, No.1, Shizishan street, Wuhan, 430070, Hubei, China.
Background: Megalobrama amblycephala presents unsynchronized growth, which affects its productivity and profitability. The liver is essential for substance exchange and energy metabolism, significantly influencing the growth of fish.
Results: To investigate the differential metabolites and genes governing growth, and understand the mechanism underlying their unsynchronized growth, we conducted comprehensive transcriptomic and metabolomic analyses of liver from fast-growing (FG) and slow-growing (SG) M.
J Biol Chem
January 2025
Nutritional Sciences Graduate Program, Rutgers University, New Brunswick, New Jersey, United States; Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey, United States; Department of Nutritional Sciences, Rutgers University, New Brunswick, New Jersey, United States; Endocrinology and Animal Biosciences Graduate Program, Rutgers University, New Brunswick, New Jersey, United States; New Jersey Institute for Food, Nutrition and Health, Rutgers University, New Brunswick, New Jersey, United States. Electronic address:
Amino acid starvation by the chemotherapy agent asparaginase is a potent activator of the integrated stress response (ISR) in liver and can upregulate autophagy in some cell types. We hypothesized that autophagy related 7 (ATG7), a protein that is essential for autophagy and an ISR target gene, was necessary during exposure to asparaginase to maintain liver health. We knocked down Atg7 systemically (Atg7) or in hepatocytes only (ls-Atg7KO) in mice before exposure to pegylated asparaginase for 5 d.
View Article and Find Full Text PDFJ Clin Med
December 2024
Ist Department of Radiology and Diagnostics Imaging, Faculty of Medicine, Medical University of Lodz, Narutowicza 60, 90-136 Lodz, Poland.
Posttraumatic upper gastrointestinal bleeding (UGIB) is a very rare consequence of blunt liver trauma. It can be quite a diagnostic challenge for clinicians, as it can clinically manifest many weeks after the trauma or be scantily symptomatic. The following article would like to provide an analysis of clinical cases of 13 patients following blunt liver injuries, the main symptoms of which was bleeding into the gastrointestinal tract through the biliary tree.
View Article and Find Full Text PDFJ Pediatr Surg
December 2024
Department of Emergency and Critical Care Medicine, Keio University School of Medicine, Tokyo, Japan.
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