Trough cerebrospinal fluid (CSF) ceftriaxone concentrations were measured daily to investigate the effect of dexamethasone on ceftriaxone penetration into CSF in adult patients with acute bacterial meningitis. Patients were divided into two groups in this double blind randomized study. In group 1 (n=6) patients were given ceftriaxone with dexamethasone whereas in group 2 (n=6) patients were only administered ceftriaxone. Plasma and CSF samples were collected at 24, 48, 72, 96 and 264 h following the study treatments. The trough CSF ceftriaxone concentrations were measured using high performance liquid chromatography (HPLC) and microbiological assay. CSF ceftriaxone concentrations were 3.21 mg/l at 24 h in group 1 and 4.85 mg/l at the same time in group 2 by HPLC. Although microbiological assay results were lower than HPLC the trough CSF ceftriaxone concentrations in dexamethasone group were at least 10(3) times higher than the minimum inhibitory concentrations of the susceptible strains. It was concluded that the ceftriaxone concentration in CSF was adequate and ceftriaxone penetration was not significantly affected by concomitant dexamethasone use in adult patients with acute bacterial meningitis.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s0924-8579(03)00041-4 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
SARS-CoV-2 Infection of the Central Nervous System: A Case Report.
Viruses
December 2024
Department of Medical Oncology, Medical University of Sofia, University Hospital "Tsaritsa Yoanna", 1527 Sofia, Bulgaria.
Central nervous system (CNS) infections caused by SARS-CoV-2 are uncommon. This case report describes the clinical progression of a 92-year-old female who developed a persistent neuroinfection associated with SARS-CoV-2. The patient initially presented with progressive fatigue, catarrhal symptoms, and a fever (38.
View Article and Find Full Text PDFMeningitis due to Gemella sp. in a patient with severe ENT conditions: case report and review of the literature.
Ann Clin Microbiol Antimicrob
December 2024
Laboratoire de Microbiologie, Centre Hospitalier de Valenciennes, Valenciennes, F-59300, France.
In June 2022, a 73-year-old man with a history of laryngeal and esophageal carcinoma was admitted to the emergency unit with sudden fever, confusion, and general condition deterioration. Initial assessments showed a fever of 38.5 °C, elevated C-reactive protein (CRP) at 209 mg/L, and a neutrophil count of 10.
View Article and Find Full Text PDFCase report: diagnosis of neurobrucellosis in a non-endemic area child using metagenomic next-generation sequencing.
Eur J Clin Microbiol Infect Dis
December 2024
Second Department of Infectious Disease, Kunming Children's Hospital, Kunming, Yunnan, 650000, China.
Brucellosis with neurological symptoms at onset is rare in children and is frequently misdiagnosed or overlooked due to nonspecific clinical presentations, particularly in non-endemic areas. We report a case of neurobrucellosis in a child from a non-pastoral area, diagnosed via metagenomic next-generation sequencing (mNGS). The patient presented with headache and altered consciousness, accompanied by fever, projectile vomiting, seizures, and urinary incontinence.
View Article and Find Full Text PDFAnalysis of Neurosyphilis Imaging Methods and Treatment: A Focused Review.
Cureus
November 2024
Medical Education, Geisinger Commonwealth School of Medicine, Scranton, USA.
Article Synopsis
- * Diagnosis relies on cerebrospinal fluid analysis and neuroimaging techniques like MRI and SPECT, and there are recent advances in testing methods and imaging to monitor treatment effectiveness.
- * The main treatment is Penicillin G, while ceftriaxone is an alternative for those allergic to penicillin; both aim to improve patient outcomes by enhancing understanding of neurosyphilis pathophysiology and refining diagnostic and treatment methods.
Endoscopic nasal multilevel skull base reconstruction combined with lumbar cistern drainage in the treatment of infection caused by cerebrospinal fluid leakage: A case report.
Medicine (Baltimore)
November 2024
Department of Neurosurgery, Liaocheng People's Hospital, Liaocheng, Shandong, China.
Rationale: Traumatic cerebrospinal fluid leakage can cause complications such as meningitis, ventriculitis and brain abscess. It is necessary to formulate individualized treatment strategies, such as the use of antibiotics and skull base reconstruction methods. The application of nasal septum mucosal flap can significantly reduce the incidence of cerebrospinal fluid leakage.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!