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Influence of forage-to-concentrate ratio on the effects of a radiata pine bark extract on methane production and fermentation using the rumen simulation technique.
Animal
December 2024
Department of Animal Science, Faculty of Veterinary Sciences, Universidad de Concepción, Campus Chillán, Chillán 3812120, Chile. Electronic address:
Climate change and food safety standards have intensified research into plant-based compounds as alternatives to dietary supplements in animal feed. These compounds can reduce enteric methane (CH) emissions and the formation of ruminal ammonia. This study investigated the effects of radiata pine bark extract (PBE) supplementation on CH production, ruminal fermentation parameters, and nutrient disappearance using the rumen simulation technique in diets with different forage-to-concentrate (F:C) ratios.
View Article and Find Full Text PDFComputational Methods for Predicting Chemical Reactivity of Covalent Compounds.
J Chem Inf Model
January 2025
Department of Medicinal Chemistry, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, People's Republic of China.
In recent decades, covalent inhibitors have emerged as a promising strategy for therapeutic development, leveraging their unique mechanism of forming covalent bonds with target proteins. This approach offers advantages such as prolonged drug efficacy, precise targeting, and the potential to overcome resistance. However, the inherent reactivity of covalent compounds presents significant challenges, leading to off-target effects and toxicities.
View Article and Find Full Text PDFDevelopment of a rapid antigen-based lateral flow assay for tick-borne spotted fever rickettsioses.
PLoS One
January 2025
Department of Pathology, University of Texas Medical Branch, Galveston, Texas, United States of America.
Tick-borne spotted fever rickettsioses (SFRs) continue to cause severe illness and death in otherwise-healthy individuals due to lack of a timely and reliable diagnostic laboratory test. We recently identified a diagnostic biomarker for SFRs, the putative N-acetylmuramoyl-l-alanine amidase RC0497. Here, we developed a prototype laboratory test that targets RC0497 for diagnosis of SFRs.
View Article and Find Full Text PDFField-scale detection of Bacterial Leaf Blight in rice based on UAV multispectral imaging and deep learning frameworks.
PLoS One
January 2025
Rice Department, Bangkok, Thailand.
Bacterial Leaf Blight (BLB) usually attacks rice in the flowering stage and can cause yield losses of up to 50% in severely infected fields. The resulting yield losses severely impact farmers, necessitating compensation from the regulatory authorities. This study introduces a new pipeline specifically designed for detecting BLB in rice fields using unmanned aerial vehicle (UAV) imagery.
View Article and Find Full Text PDFPermeability Benchmarking: Guidelines for Comparing , , and Measurements.
J Chem Inf Model
January 2025
Dept. of Engineering, King's College London, London WC2R 2LS, U.K.
Permeability is a measure of the degree to which cells can transport molecules across biological barriers. Units of permeability are distance per unit time (typically cm/s), where accurate measurements are needed to define drug delivery in homeostasis and to model dysfunction occurring during disease. This perspective offers a set of community-led guidelines to benchmark permeability data across multidisciplinary approaches and different biological contexts.
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