AI Article Synopsis
- A study evaluated the effectiveness of meso-dimercaptosuccinic acid (DMSA) in treating birds with lead poisoning, focusing on those showing signs of neurological distress.
- Nineteen birds received DMSA treatment for at least 7 days, and four of these cases with severe symptoms also received an additional treatment with edetate calcium disodium.
- Results showed a significant 87% reduction in blood lead levels, complete resolution of neurologic signs, and no noticeable side effects from the treatments.
Article Abstract
The efficacy of meso-dimercaptosuccinic acid (DMSA) (succimer) in treating avian lead intoxication was studied in a retrospective, nonrandomized, longitudinal study. Nineteen birds with moderate to high blood lead concentration and neurologic signs compatible with lead toxicity were treated with DMSA (30 mg/kg p.o., b.i.d.; n = 15) for a minimum of 7 days. In cases with severe neurologic signs, DMSA was supplemented with a single dose of edetate calcium disodium (<50.0 mg/kg of body weight i.m.; n = 4). Blood lead concentrations were measured two or more times (before and after treatment). Median blood lead concentration decreased (87%), neurologic signs were resolved, and there were no apparent adverse secondary effects.
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| http://dx.doi.org/10.1638/1042-7260(2003)34[0082:OTOALI]2.0.CO;2 | DOI Listing |
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