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Evolution of the Mitogenome: Insights Into the Mitogenomic Evolution of the Orders Siphonaptera and the Phthiraptera.
Ecol Evol
March 2025
Yunnan Provincial Key Laboratory for Zoonosis Control and Prevention, Institute of Pathogens and Vectors Dali University Dali Yunnan China.
The evidence that parasitic animals exhibit elevated mitogenomic evolution rates is inconsistent and limited to Arthropoda. Li, Bai et Chen, 1986 (Siphonaptera: Ctenophthalmidae) feeds on the host's blood and is an important medical insect with plague transmission. In this study, we sequenced the mitogenome and explored the mitogenomic evolution of Siphonaptera and Phthiraptera, which both belong to the Insecta on warm-blooded animals.
View Article and Find Full Text PDFImpact of Microstructure on the In Situ Formation of LDH Coatings on AZ91 Magnesium Alloy.
Materials (Basel)
March 2025
Key Laboratory of Automobile Materials, Ministry of Education, College of Materials Science and Engineering, Jilin University, Changchun 130022, China.
Layered Double Hydroxide (LDH) coatings were synthesized on as-cast, T4 (solution treatment), and T6 (aging treatment) AZ91 magnesium alloys using a hydrothermal method. XRD (X-Ray Diffraction) and SEM (Scanning Electron Microscope) analyses showed that the large β-phases in as-cast AZ91 initially promoted LDH growth via galvanic corrosion, but later compromised coating integrity. In contrast, T6 and T4 alloys, with refined microstructures, formed uniform and compact LDH coatings.
View Article and Find Full Text PDFRat Model of Endogenous and Exogenous Hyperammonaemia Induced by Different Diets.
Int J Mol Sci
February 2025
Anara AB, 23132 Trelleborg, Sweden.
Two different diets able to induce dietary hyperammonaemia (a methionine-choline-deficient (MCD) diet and a methionine-deficient diet enriched with ammonium acetate (MAD + 20% ammonium acetate)) were tested in a rat model. The diets were shown to have different modes of action, inducing significant hyperammonaemia (HA) and growth retardation in the rats, with different metabolic consequences. The MCD diet resulted in the development of endogenous HA, with a decrease in bilirubin levels and an increase in hepatic fat content.
View Article and Find Full Text PDFPharmacokinetic and pharmacodynamic assessment of oral nicotinamide in the NEAT clinical trial for early Alzheimer's disease.
Alzheimers Res Ther
March 2025
Department of Biomedical Engineering, University of California, Irvine, CA, USA.
Background: Nicotinamide, a form of B3 vitamin, is an NAD precursor that reduces pTau levels via histone deacetylase inhibition in murine models of Alzheimer's disease (AD). A recent phase 2a randomized placebo-controlled trial tested high-dose oral nicotinamide for the treatment of early AD. While nicotinamide demonstrated good safety and tolerability, it did not significantly lower CSF pTau, the primary biomarker endpoint of the study.
View Article and Find Full Text PDFVagal heart rate variability during rapid eye movement sleep reduces negative memory bias.
Front Behav Neurosci
February 2025
Department of Cognitive Science, University of California, Irvine, CA, United States.
Emotional memories change over time, but the mechanisms supporting this change are not well understood. Sleep has been identified as one mechanism that supports memory consolidation, with sleep selectively benefitting negative emotional consolidation at the expense of neutral memories, with specific oscillatory events linked to this process. In contrast, the consolidation of neutral and positive memories, compared to negative memories, has been associated with increased vagally mediated heart rate variability (HRV) during wakefulness.
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