Blisters and erosions localized to genital mucous membranes often accompany various diseases and may cause significant diagnostic difficulties. Autoimmune bullous diseases (pemphigus, pemphigoid, LABD, EBA), characterized by skin and mucosal lesions, sometimes are limited only to genital mucous membranes. The possibility of the autoimmune bullous disorders should be considered in the differential diagnosis of genital tract ulceration because of severity of those diseases and the necessity of long-term immunosuppressive therapy. The correct diagnosis of autoimmune bullous diseases is established by immunofluorescence tests (DIF, IIF).
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